PLA2G5: A Potential Drug Target and Biomarker (G5322)

Target Name: PLA2G5

NCBI ID: G5322

PLA2G5

PLA2G5: A Potential Drug Target and Biomarker

PLA2G5 (hVPLA(2)) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It is a member of the PLA2 family of proteins, which are involved in the regulation of cellular processes such as cell adhesion, migration, and inflammation.

One of the unique features of PLA2G5 is its ability to interact with several different types of cell surface molecules, including cadherins, integrins, and G-protein-coupled receptors. This interaction with these molecules makes PLA2G5 a potentially useful drug target or biomarker, as it can be targeted with small molecules or antibodies to modulate its activity and improve therapeutic outcomes.

PLA2G5 has been shown to play a role in several biological processes, including the regulation of cell proliferation, differentiation, and survival. In addition, it has been implicated in the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the most promising aspects of PLA2G5 is its potential as a drug target. The ability of PLA2G5 to interact with multiple cell surface molecules makes it an attractive target for small molecules or antibodies that can modulate its activity. For example, several studies have shown that inhibiting PLA2G5 can reduce the growth and migration of cancer cells, suggesting that it may be an effective strategy for cancer treatment.

In addition to its potential as a drug target, PLA2G5 has also been shown to be a potential biomarker for several diseases. For example, several studies have shown that PLA2G5 levels are elevated in the brains of individuals with Alzheimer's disease, a neurodegenerative disorder. This suggests that PLA2G5 may be a useful biomarker for the diagnosis and treatment of this disease.

Another promising aspect of PLA2G5 is its role in the regulation of cellular processes that are important for maintaining tissue homeostasis. Several studies have shown that PLA2G5 plays a role in regulating the migration and adhesion of immune cells, which are critical for protecting the body against infection and disease.

In conclusion, PLA2G5 is a protein that has been shown to play a critical role in several biological processes that are important for maintaining tissue homeostasis. Its potential as a drug target or biomarker makes it an attractive target for small molecules or antibodies that can modulate its activity. Further research is needed to fully understand the role of PLA2G5 in disease and to develop effective treatments.

Protein Name: Phospholipase A2 Group V

Functions: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:8300559, PubMed:14998370, PubMed:23533611). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (PubMed:23533611). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (PubMed:25725101). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (PubMed:12124392, PubMed:12796497). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (PubMed:12796497). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (PubMed:12124392). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370)

The "PLA2G5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLA2G5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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