Localized Role of EIF3J-DT in Post-Transcriptional Modification and MiRNA Regulation

Target Name: EIF3J-DT

NCBI ID: G645212

EIF3J-DT

Other Name(s): EIF3J divergent transcript | EIF3J divergent transcript, transcript variant 1 | EIF3J-DT variant 1 | EIF3J-AS1

Localized Role of EIF3J-DT in Post-Transcriptional Modification and MiRNA Regulation

EIF3J-DT, also known as EIF3J-DNA, is a protein that is expressed in the brain and is known for its role in the regulation of gene expression. It is a key player in the post-transcriptional modification (RNA modification) pathway, which is the process by which RNA molecules are modified to facilitate their function in the cell.

One of the key functions of EIF3J-DT is its ability to localize to specific gene promoters in the nucleus. This localization is important for the regulation of gene expression, as it allows the protein to interact with the RNA of the target genes. Additionally, EIF3J-DT can also interact with the protein SMY3, which is involved in the modification of DNA methylation. This interaction between EIF3J-DT and SMY3 can lead to the modification of DNA methylation patterns in the promoter region of the target genes, which can in turn affect gene expression.

Another function of EIF3J-DT is its role in the regulation of microRNA (miRNA) levels. MiRNA is a small non-coding RNA molecule that plays a critical role in post-transcriptional gene regulation. EIF3J-DT has been shown to interact with the miRNA machinery, leading to the regulation of miRNA levels. This regulation of miRNA levels can have a significant impact on gene expression and can be a potential drug target.

In addition to its role in gene regulation, EIF3J-DT has also been shown to play a role in the regulation of cellular processes such as cell division, apoptosis, and autophagy. It has been shown to localize to the endoplasmic reticulum (ER) and to be involved in the regulation of the ER-associated degradation (ERAD) pathway, which is involved in the clearance of damaged or unnecessary proteins from the ER.

EIF3J-DT has also been shown to play a role in the regulation of inflammation. It has been shown to localize to the nuclear immune response element (NISPE), which is a region of the genome that is involved in the regulation of immune responses. This localization is thought to play a role in the regulation of the expression of immune genes.

In conclusion, EIF3J-DT is a protein that is involved in a variety of cellular processes and has been shown to play a role in the regulation of gene expression, microRNA levels, cell division, apoptosis, and autophagy. Its localization to specific gene promoters and its interaction with the miRNA machinery and ERAD pathway suggest that it may be a potential drug target. Further research is needed to fully understand the role of EIF3J-DT in cellular processes and its potential as a drug target.

Protein Name: EIF3J Divergent Transcript

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