SLC5A2: Structure, Function and Drug Targets (G6524)

Target Name: SLC5A2

NCBI ID: G6524

SLC5A2

SLC5A2: Structure, Function and Drug Targets

SLC5A2 (sulfate transporting ATPase isoform 5) is a protein widely expressed in many cell types, and its main function is to promote intracellular sulfate ion transport. It plays an important role within cells and is a key participant in a variety of biochemical reactions. In addition, SLC5A2 is also considered to be a target of many drugs and chemicals, and therefore has become a subject of much attention. This article will introduce in detail the structure, function, drug targets of SLC5A2 and its potential role in drug discovery.

1. Structure

SLC5A2 is a protein that belongs to the sulfate transporter family. Its molecular structure is a transmembrane protein, which is mainly expressed and functions through the cell membrane. The molecular structure of SLC5A2 consists of two subunits, each subunit contains an extracellular 伪-helix and an intracellular 尾-sheet. The two subunits interact through a hydrophobic 尾-curl to form a continuous three-dimensional structure. The extracellular domain of SLC5A2 contains a bright 伪-helix, a transmembrane region of 34 amino acid residues, and a bright 尾-sheet, a transmembrane region of 34 amino acid residues. The intracellular domain contains a bright 伪-helix, a transmembrane region of 25 amino acid residues, and a bright 尾-sheet, a transmembrane region of 25 amino acid residues. In addition, the intracellular region of SLC5A2 also contains a hydrophobic tail that can interact with other proteins in the cell and thus participate in the transport of materials inside and outside the cell.

2. Function

SLC5A2 plays an important role in cells and is a key participant in sulfate ion transport. Sulfate ion is an important intracellular ion. It plays many important physiological roles in cells, including regulating the osmotic pressure inside and outside the cell, participating in cell signal transmission, and regulating cell metabolism. SLC5A2 maintains the ion balance inside and outside the cell by promoting the transport of sulfate ions, thus ensuring the normal physiological functions of cells.

In addition, SLC5A2 is also involved in many important metabolic processes. For example, SLC5A2 can promote glucose transport and thus participate in intracellular glucose metabolism; it can also promote fatty acid transport and participate in intracellular fat metabolism. SLC5A2 is also involved in many important signal transduction processes within cells.

Protein Name: Solute Carrier Family 5 Member 2

Functions: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity)

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