SLC9A4: Potential Drug Target and Biomarker (G389015)

Target Name: SLC9A4

NCBI ID: G389015

SLC9A4

SLC9A4: Potential Drug Target and Biomarker

SLC9A4 (also known as DKFZp313B031) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the sulfate transport family 9, which includes proteins that transport sulfates across cell membranes. SLC9A4 is primarily localized to the endoplasmic reticulum (ER), where it is involved in the transport of various sulfates, including cysteine and glutathione.

SLC9A4 is a potential drug target and has been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its involvement in the transport of cysteine and glutathione suggests that it may play a role in the detoxification of these molecules, which can be abnormally generated or consumed in certain diseases.

One of the key challenges in studying SLC9A4 is its limited expression and its prevalence across various tissues. While it is expressed in many tissues, its expression is often low, and it can be difficult to detect and quantify. This has led to some researchers questioning its relevance as a drug target or biomarker.

However, recent studies have suggested that SLC9A4 may have a more significant role in certain diseases than previously thought. For example, some researchers have found that high levels of SLC9A4 are associated with increased risk of certain neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Additionally, SLC9A4 has been shown to be involved in the regulation of cellular processes that are important for brain development and function, such as the production of neurotransmitters and the modulation of ion channels.

Furthermore, some studies have suggested that SLC9A4 may be a potential target for cancer therapies. For example, some researchers have found that inhibiting SLC9A4 activity can reduce the formation of cancer cells, suggesting that it may be a useful target for cancer therapies. Additionally, SLC9A4 has been shown to be involved in the regulation of cell division and apoptosis, which are important processes that are often disrupted in cancer cells.

In conclusion, SLC9A4 is a protein that is expressed in various tissues throughout the body and is involved in the transport of cysteine and glutathione. While its limited expression and prevalence across tissues have hindered its study, recent studies have suggested that it may play a more significant role in the development and progression of certain diseases, including cancer and neurodegenerative disorders. Further research is needed to fully understand the potential implications of SLC9A4 as a drug target and biomarker.

Protein Name: Solute Carrier Family 9 Member A4

Functions: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity)

The "SLC9A4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC9A4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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