SLCO1A2: Unlocking The Potential of An Understudied Protein (G6579)

Target Name: SLCO1A2

NCBI ID: G6579

SLCO1A2

SLCO1A2: Unlocking The Potential of An Understudied Protein

SLCO1A2 (Solute carrier organic anion transporter family member 1A2) is a protein that is expressed in many different tissues throughout the body. It is a member of the SLCO1A2 family, which is a group of transporters that are involved in the transport of organic anions, such as chloride and other types of anions. SLCO1A2 is primarily expressed in the liver, but it is also found in other tissues, including the kidneys, heart, and lungs.

SLCO1A2 is involved in many different processes in the body. In the liver, it is responsible for transporting chloride anions out of the cell and into the bloodstream. This is important for maintaining the proper balance of fluids and electrolytes in the body. SLCO1A2 is also involved in the transport of other types of anions, such as bicarbonate and sulfate.

SLCO1A2 has also been shown to play a role in several different diseases. For example, it has been associated with the development of certain types of cancer, such as breast cancer and ovarian cancer. It has also been shown to be involved in the development of several other diseases, including cardiovascular disease and neurodegenerative diseases.

Despite these promising findings, much more research is needed about SLCO1A2 and its role in the body. Currently, there are no FDA-approved drugs that are specifically designed to target SLCO1A2. Researchers are still working to develop new treatments for diseases that are associated with SLCO1A2, but in the meantime, they are using the protein as a potential biomarker to diagnose and diagnose certain diseases.

One approach that researchers are using to study SLCO1A2 is through the use of genetic testing. By analyzing the genetic makeup of individuals who have been diagnosed with certain diseases, researchers can identify any genetic variations that are associated with the disease. By identifying these variations, researchers can then use them to develop new treatments or biomarkers for the disease.

Another approach that researchers are using to study SLCO1A2 is through the use of biochemical assays. These assays can be used to measure the level of SLCO1A2 in different tissues or cells, which can provide insight into its function and how it is involved in the development of certain diseases.

While there is still much to be learned about SLCO1A2, its potential as a drug target is significant. Researchers are actively working to identify new ways to use SLCO1A2 as a treatment or biomarker for a variety of diseases. As more research is done, it is likely that we will learn even more about this important protein and its role in the body.

Protein Name: Solute Carrier Organic Anion Transporter Family Member 1A2

Functions: Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane (PubMed:7557095, PubMed:19129463). Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate) (PubMed:9539145, PubMed:23918469, PubMed:25560245, PubMed:12568656, PubMed:11159893, PubMed:19129463). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision (PubMed:25560245). Involved in the uptake of clinically used drugs (PubMed:17301733, PubMed:20686826, PubMed:27777271). Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (PubMed:20358049, PubMed:19129463). Also transports prostaglandin E2 (PubMed:19129463). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)

The "SLCO1A2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLCO1A2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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