Understanding SLCO4C1: A Potential Drug Target (G353189)

Target Name: SLCO4C1

NCBI ID: G353189

SLCO4C1

Understanding SLCO4C1: A Potential Drug Target

SLCO4C1 (PRO2176) is a protein that is expressed in various tissues throughout the body. It is a member of the superfamily A (SPOP) and is characterized by the presence of a unique transmembrane domain and a cytoplasmic tail. SLCO4C1 has been identified as a potential drug target (PRO2176) and has been shown to play a role in a variety of cellular processes.

SLCO4C1 is expressed in a variety of tissues, including the brain, heart, liver, and pancreas. It is highly expressed in the liver, with lower levels found in the heart, brain, and pancreas. SLCO4C1 is also expressed in the placenta, which may be a promising target for drug development.

SLCO4C1 has been shown to play a role in a variety of cellular processes. One of its well-known functions is its role in cell signaling. SLCO4C1 has been shown to be involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues.

SLCO4C1 is also involved in the regulation of cell survival. Studies have shown that SLCO4C1 plays a role in the regulation of cell survival by promoting the expression of genes that promote cell proliferation and survival.

In addition to its role in cell signaling and survival, SLCO4C1 has also been shown to play a role in the regulation of inflammation. Studies have shown that SLCO4C1 is involved in the regulation of inflammation by promoting the expression of genes that contribute to inflammation.

SLCO4C1 has also been shown to play a role in the regulation of protein synthesis. Studies have shown that SLCO4C1 is involved in the regulation of protein synthesis by promoting the translation of genes into proteins.

Despite its many functions, SLCO4C1 is not well understood. Currently, there are no known drugs that specifically target SLCO4C1. However, studies have shown that inhibiting the activity of SLCO4C1 has potential therapeutic benefits. For example, studies have shown that inhibiting the activity of SLCO4C1 has potential anti-inflammatory effects.

In conclusion, SLCO4C1 is a protein that is expressed in various tissues throughout the body. It is a member of the superfamily A (SPOP) and is characterized by the presence of a unique transmembrane domain and a cytoplasmic tail. SLCO4C1 has been identified as a potential drug target (PRO2176) and has been shown to play a role in a variety of cellular processes. Further research is needed to fully understand the role of SLCO4C1 in cell signaling and biology.

Protein Name: Solute Carrier Organic Anion Transporter Family Member 4C1

Functions: Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity)

The "SLCO4C1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLCO4C1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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