SLIT1: A Multiple EGF-like Domains Protein 4 as a Drug Target and Biomarker

Target Name: SLIT1

NCBI ID: G6585

SLIT1

SLIT1: A Multiple EGF-like Domains Protein 4 as a Drug Target and Biomarker

SLIT1 (Multiple EGF-like domains protein 4) is a protein that has been identified as a potential drug target and biomarker. It is a member of the SLIT family, which includes several structurally similar proteins that have been shown to play important roles in various cellular processes, including cell signaling, migration, and invasion. The SLIT1 protein has unique multiple EGF-like domains, which give it a unique structure and function.

SLIT1: Structure and Function

The SLIT1 protein is 22 kDa in size and has a molecular weight of 30 kDa. It has a single transmembrane domain and a cytoplasmic tail. The cytoplasmic tail is composed of 120 amino acid residues and includes a unique N-terminal domain that is rich in electrostatic and hydrophobic interactions.

The SLIT1 protein has multiple EGF-like domains, which are located in different regions of the protein. The first EGF-like domain is located at the N-terminus of the protein and consists of 12 amino acid residues. This domain has been shown to play a role in SLIT1-mediated cell signaling.

The second EGF-like domain is located in the middle of the protein and consists of 18 amino acid residues. This domain has been shown to play a role in SLIT1-mediated cell adhesion.

The third EGF-like domain is located at the C-terminus of the protein and consists of 20 amino acid residues. This domain has been shown to play a role in SLIT1-mediated cell migration and invasion.

SLIT1 has been shown to play a role in various cellular processes, including cell signaling, migration, and invasion. For example, SLIT1 has been shown to be involved in the regulation of cell signaling pathways, including the TGF-β pathway. This is thought to occur through the regulation of the SMAD signaling pathway, which is a critical pathway involved in the regulation of cell growth and differentiation.

SLIT1 has also been shown to play a role in cell migration and invasion. For example, SLIT1 has been shown to be involved in the regulation of the guidance cascade in various tissues, including the regulation of chemotactic factor-induced cell migration.

In addition to its role in cell signaling and migration, SLIT1 has also been shown to play a role in the regulation of inflammation. For example, SLIT1 has been shown to be involved in the regulation of the production and response to bacterial chemotactic factors, which are involved in the regulation of inflammation.

SLIT1 as a Drug Target

The unique multiple EGF-like domains of SLIT1 make it a potential drug target. The N-terminal and C-terminus domains of SLIT1 have been shown to be involved in SLIT1-mediated cell signaling, migration, and invasion, making them potential targets for small molecules that can modulate these processes.

Various small molecules have been shown to be able to modulate SLIT1 signaling, including inhibitors of the FAK/SLIT1 interaction and modulators of the FAK/PI3K signaling pathway. These small molecules have been shown to have a variety of effects on cellular processes, including the regulation of cell signaling, migration, and invasion.

SLIT1 as a Biomarker

In addition to its role as a drug target, SLIT1 has also been shown to be a potential biomarker. The unique multiple EGF-like domains of SLIT1 have been shown to be involved in the regulation of various cellular processes, including cell signaling, migration, and invasion. This makes these domains potential targets for biomarkers that can be used to monitor these processes.

For example, SLIT1 has

Protein Name: Slit Guidance Ligand 1

Functions: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb

The "SLIT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLIT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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