SLC7A11: A Protein Involved in Neurotransmission and Cellular Functions

Target Name: SLC7A11

NCBI ID: G23657

SLC7A11

SLC7A11: A Protein Involved in Neurotransmission and Cellular Functions

SLC7A11 is a protein that is expressed in various tissues throughout the body. It is a member of the SLC7A family, which is known for its role in transmembrane transport of small molecules. SLC7A11 is primarily expressed in the brain, where it is involved in the transport of a variety of molecules, including neurotransmitters and other substances that are essential for brain function.

One of the unique features of SLC7A11 is its structure. It is a transmembrane protein, which means that it spans the cell membrane and is expressed in the cell's outer layer. This allows it to play a critical role in the regulation of the brain's chemical environment, as well as the delivery and uptake of substances within the cell.

SLC7A11 is also known for its role in the regulation of ion channels. In particular, it is expressed in the postsynaptic density of neurons, which is the layer of nerve cells that connects the brain to the rest of the body. This allows SLC7A11 to influence the flow of electrical current through the neuron, which is critical for the transmission of signals.

Another key function of SLC7A11 is its role in the regulation of neurotransmitter release. Neurotransmitters are the chemical messengers that are used by the brain to communicate with other cells and organs. SLC7A11 is involved in the release of these neurotransmitters, as well as the regulation of their reabsorption from the synaptic vesicles.

SLC7A11 is also expressed in other tissues, including the heart and the kidneys. This suggests that it may be involved in the regulation of ion channels and neurotransmitter release in these tissues as well.

Despite its importance in various physiological processes, SLC7A11 is not yet a well-studied protein. There are currently very few studies that have focused on its role in neurotransmission, and much of our knowledge about it comes from experimental animals or cell-based studies.

However, because of its involvement in the regulation of neurotransmitter release and the transport of other molecules, SLC7A11 is an attractive target for drug development. Studies have shown that inhibitors of SLC7A11 have the potential to block the activity of neurotransmitters, such as dopamine and serotonin, which could be useful for the treatment of various psychiatric and neurological disorders.

In addition, SLC7A11 may also be a useful biomarker for certain neurological disorders. For example, some studies have suggested that levels of SLC7A11 may be elevated in the brains of individuals with Alzheimer's disease, a condition that is characterized by the progressive loss of brain cells that are responsible for memory and other cognitive functions.

Overall, SLC7A11 is a protein that is involved in a variety of important physiological processes in the brain. While more research is needed, its potential as a drug target or biomarker makes it an intriguing target for further study.

Protein Name: Solute Carrier Family 7 Member 11

Functions: Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:15151999, PubMed:34880232, PubMed:35352032, PubMed:35245456, PubMed:11417227, PubMed:14722095, PubMed:11133847). Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress (By similarity). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine (PubMed:11417227, PubMed:11133847). In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis (PubMed:35245456). Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis (PubMed:34120018). In vitro can also transport L-aspartate (PubMed:11417227). May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (By similarity). Controls the production of pheomelanin pigment directly (By similarity)

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