SLCO2B1: A Protein Involved in Cell Regulation and Drug Targeting

Target Name: SLCO2B1

NCBI ID: G11309

SLCO2B1

SLCO2B1: A Protein Involved in Cell Regulation and Drug Targeting

SLCO2B1 (Sodium Chloride Channel, OATPB) is a protein that is expressed in many different tissues throughout the body. It is a key component of the sodium chloride transport system, which is responsible for regulating the movement of sodium ions into and out of cells. SLCO2B1 is also known as OATPB, which stands for Oxygen-Binding Protein.

SLCO2B1 is a transmembrane protein that is composed of four distinct subunits. It has a paxidromic structure, which means that it has a unique arrangement of its subunits that allows it to transport oxygen across the cell membrane. SLCO2B1 is primarily localized to the endoplasmic reticulum, which is the membrane-bound organelles that enclose the cell's intracellular structures.

SLCO2B1 plays a critical role in the regulation of cellular processes that are dependent on the proper functioning of the endoplasmic reticulum. It is responsible for controlling the movement of oxygen into the endoplasmic reticulum, which is necessary for the production of new proteins and for the biosynthesis of other molecules that are essential to cellular life.

SLCO2B1 is also involved in the regulation of the levels of intracellular calcium ions, which are essential for many different cellular processes. It does this by controlling the movement of calcium ions out of the endoplasmic reticulum, which helps to maintain the proper levels of calcium ions in the cytosol of the cell.

SLCO2B1 is a protein that is expressed in many different tissues throughout the body, including the brain, heart, and kidneys. It is also expressed in the placenta, which is the tissue that provides nutrients and oxygen to the developing fetus. SLCO2B1 is thought to be involved in the regulation of many different cellular processes that are dependent on the proper functioning of the endoplasmic reticulum.

SLCO2B1 is a potential drug target, which means that it is a target for therapeutic intervention. Researchers are currently working to develop drugs that can specifically target SLCO2B1 and modulate its activity to treat a variety of different conditions. For example, some researchers are studying the potential therapeutic benefits of drugs that can specifically target SLCO2B1 to treat various neurological and psychiatric disorders, such as Alzheimer's disease and depression.

In addition to its potential as a drug target, SLCO2B1 is also a potential biomarker. Researchers are studying the expression and function of SLCO2B1 to gain insight into the underlying mechanisms of many different cellular processes. This information can be used to develop new diagnostic tests and to understand the mechanisms of many different diseases.

Overall, SLCO2B1 is a protein that is expressed in many different tissues throughout the body and plays a critical role in the regulation of many different cellular processes. Its unique paxidromic structure and its involvement in the regulation of oxygen and calcium ions make it an attractive target for therapeutic intervention and a potential biomarker. Further research is needed to fully understand the mechanisms of SLCO2B1 and its role in the regulation of cellular processes.

Protein Name: Solute Carrier Organic Anion Transporter Family Member 2B1

Functions: Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions (PubMed:10873595, PubMed:11159893, PubMed:11932330, PubMed:12724351, PubMed:14610227, PubMed:16908597, PubMed:18501590, PubMed:20507927, PubMed:22201122, PubMed:23531488, PubMed:25132355, PubMed:27576593, PubMed:26383540, PubMed:28408210, PubMed:29871943, PubMed:34628357). Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S) (PubMed:11932330, PubMed:12409283). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver (PubMed:11159893). Mediates the intestinal uptake of sulfated steroids (PubMed:12724351, PubMed:28408210). Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain (PubMed:16908597, PubMed:25132355). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May act as a heme transporter that promotes cellular iron availability via heme oxygenase/HMOX2 and independently of TFRC (PubMed:35714613). Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (PubMed:26383540). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:10873595, PubMed:14610227, PubMed:19129463, Ref.24, PubMed:29871943). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:14610227, PubMed:19129463, PubMed:22201122). The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound (PubMed:19129463, PubMed:20507927, PubMed:26277985). Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions (PubMed:19129463). Cytoplasmic glutamate may also act as counteranion in the placenta (PubMed:26277985). An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (PubMed:20507927)

The "SLCO2B1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLCO2B1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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