SLCO1B7: A Liver-Specific Organic Anion Transporter 3 (G338821)

Target Name: SLCO1B7

NCBI ID: G338821

SLCO1B7

SLCO1B7: A Liver-Specific Organic Anion Transporter 3

SLCO1B7 (Liver-specific organic anion transporter 3) is a protein that is expressed in the liver and is involved in the transport of organic anions across the liver membrane. It is a member of the SLCO gene family, which encodes a family of anion transport proteins that play a critical role in the regulation of intracellular and extracellular levels of various anions, including nutrients, drugs, and toxins. The SLCO gene family has been identified as a potential drug target in the treatment of various diseases, including liver disease.

SLCO1B7 function

SLCO1B7 is a transmembrane protein that localizes to the endoplasmic reticulum (ER) and the transmembrane space. It consists of a single polypeptide chain that is composed of 115 amino acids. SLCO1B7 is expressed in the liver and other organs and is involved in the transport of a wide variety of organic anions across the liver membrane, including acyl-CoA, glutamyl-CoA, and malate.

SLCO1B7 is a member of the SLCO gene family, which encodes a family of anion transport proteins that are involved in the regulation of intracellular and extracellular levels of various anions. The SLCO gene family has been identified as a potential drug target in the treatment of various diseases, including liver disease, due to its involvement in the regulation of liver function and the transport of potential drug substrates across the liver membrane.

SLCO1B7 is expressed in various tissues and organs, including the liver, heart, kidney, and pancreas. It is also expressed in various cell types, including epithelial cells, endothelial cells, and immune cells. SLCO1B7 is involved in the regulation of cellular processes, including cellular signaling, DNA replication, and protein synthesis.

SLCO1B7 dysfunction

SLCO1B7 dysfunction has been implicated in the development and progression of various diseases, including liver disease. SLCO1B7 is involved in the regulation of the transport of organic anions across the liver membrane, which is critical for the proper functioning of the liver. Therefore, alterations in SLCO1B7 function have been implicated in the development of liver disease, including the development of fibrosis and the progression of certain types of cancer.

SLCO1B7 has also been implicated in the regulation of cellular signaling pathways that are involved in the development and progression of various diseases. For example, SLCO1B7 is involved in the regulation of the production of reactive oxygen species (ROS), which can damage cellular components and contribute to the development of oxidative stress-induced diseases. Additionally, SLCO1B7 is involved in the regulation of the production of pro-inflammatory cytokines, which can contribute to the development of inflammatory diseases.

Drug targeting SLCO1B7

SLCO1B7 is a potential drug target in the treatment of various diseases, including liver disease. Drugs that can modulate SLCO1B7 function have been shown to have therapeutic potential in the treatment of liver disease. For example, inhibitors of SLCO1B7 have been shown to have anti-inflammatory and antioxidant properties, which can help to protect against the damage caused by SLCO1B7 dysfunction.

In addition, drugs that can modulate SLCO1B7 function have been shown to be effective in treating certain types of liver disease, such as nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD). In these conditions, SLCO1B7 dysfunction is thought to contribute to the development and progression of liver disease. Therefore, drugs that can modulate SLCO1B7 function have been shown to be effective in treating these conditions.

Conclusion

SLCO1B7 is a protein that is involved in the transport of organic anions across the liver membrane. It is a member of the SLCO gene family and is expressed in various tissues and organs, including the liver. SLCO1B7 dysfunction has

Protein Name: Solute Carrier Organic Anion Transporter Family Member 1B7 (putative)

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