SLC7A3: A Protein Involved in Calcium Ion Regulation (G84889)

Target Name: SLC7A3

NCBI ID: G84889

SLC7A3

SLC7A3: A Protein Involved in Calcium Ion Regulation

SLC7A3 (Simple Localized Calcium homeostasis protein 3) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the SLC family of transmembrane proteins, which are known for their ability to regulates the transport of ions and solutes across cell membranes. One of the unique features of SLC7A3 is its ability to regulate the levels of calcium ions in the body, which are essential for various physiological processes, including muscle contractions, nerve function, and blood clotting.

SLC7A3 is a 22kDa protein that is expressed in the brain, heart, and kidneys, among other tissues. It is localized to the outer membrane of the tranquillizer cells, which is the most abundant type of neuronal cells in the brain. SLC7A3 is also expressed in the endoplasmic reticulum, which is the part of the cell that synthesizes and stores proteins, and in the cytosol, which is the fluid inside the cell.

SLC7A3 is involved in the regulation of calcium ion levels in various tissues. It is a critical regulator of the levels of calcium ions in the brain, which are essential for the proper functioning of neural cells. SLC7A3 helps to maintain the brain's calcium ion levels at a stable state, by regulating the influx and extrusion of calcium ions into the cell. This is important for maintaining the stability of the cell's membrane potential, which is critical for the transmission of electrical signals within the cell.

SLC7A3 is also involved in the regulation of calcium ion levels in the heart and kidneys. It helps to maintain the levels of calcium ions in these tissues by regulating the influx and extrusion of calcium ions into the cells. This is important for maintaining the stability of the cell's membrane potential, which is critical for the normal functioning of these tissues.

SLC7A3 is a potential drug target for various diseases, including Alzheimer's disease, Parkinson's disease, and cardiovascular disease. The disruption of SLC7A3 has been observed in the brains of individuals with these conditions, which suggests that it may play a role in the development and progression of these diseases.

In addition to its role in the regulation of calcium ion levels, SLC7A3 is also involved in the regulation of various other ions and solutes, including potassium, sodium, and magnesium. This suggests that it may be a useful biomarker for various physiological processes, including muscle contractions, nerve function, and blood clotting.

In conclusion, SLC7A3 is a unique and important protein that is involved in the regulation of various physiological processes in the body. Its ability to regulate the levels of calcium ions in the brain, heart, and kidneys makes it a potential drug target for various diseases , including Alzheimer's disease, Parkinson's disease, and cardiovascular disease. Further research is needed to fully understand the role of SLC7A3 in these processes, as well as its potential as a biomarker for various physiological conditions.

Protein Name: Solute Carrier Family 7 Member 3

Functions: Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:11591158). The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:11591158)

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•   general information;
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•   expression level;
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