GPR89A: A Potential Drug Target and Biomarker for NF-kappa-B Activation

Target Name: GPR89A

NCBI ID: G653519

GPR89A

GPR89A: A Potential Drug Target and Biomarker for NF-kappa-B Activation

Non-coding RNA (ncRNA) plays a crucial role in gene expression and have been implicated in various diseases, including neurodegenerative diseases. One of the well-known ncRNA is Putative NF-kappa-B-activating protein 90 (GPR89A) which is expressed in various diseases tissues and is involved in the neurotransmitter signaling pathway. GPR89A has been shown to activate the neurotransmitter receptor, GPR75, which is a G protein-coupled receptor that plays a role in pain modulation and neurotransmission.

GPR89A is a 12-kDa protein that is expressed in the brain and other tissues. It is a member of the G protein-coupled receptor (GPCR) family, which includes GPR75, GPR78, GPR81, GPR83, GPR85, GPR86, GPR87, GPR88 , GPR91, GPR93, GPR96, GPR97, GPR98, and GPR100. GPR89A is characterized by a N-terminal cytoplasmic domain, a catalytic C-terminal region, and a C-terminal hypervariable region (HVR).

GPR89A is involved in the neurotransmitter signaling pathway and has been shown to activate the GPR75 receptor, which is a key mediator of pain modulation. GPR75 is a GPCR that is expressed in various tissues, including the brain, and is involved in the perception of pain , neurotransmission, and neuroendocrine regulation. GPR89A has been shown to activate GPR75 in a dose-dependent manner and to play a role in the development of pain states in experimental animals.

In addition to its role in pain modulation, GPR89A is also involved in the neurotransmission of other neurotransmitters, including dopamine, GABA, and glutamate. GPR89A has been shown to interact with various neurotransmitter receptors, including GPR75, GPR78, GPR81, GPR83, GPR85, GPR86, GPR88, GPR91, GPR93, GPR96, GPR97, GPR98, and GPR100.

GPR89A has also been shown to play a role in neurotransmission in the regulation of neuronal excitability. GPR89A has been shown to regulate the intracellular calcium (Ca2+) levels in neurons and to play a role in the regulation of neuronal excitability. interact with the ion channel, Ca2+-ATPase (Ca2+-ATP), which is involved in the regulation of neuronal excitability.

GPR89A has also been shown to play a role in the regulation of inflammation. GPR89A has been shown to regulate the production of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6, in response to various stressors, including pain, stress, and neuro-inhibitors. GPR89A has been shown to interact with the transcription factor, NF-kappa-B, which is involved in the regulation of inflammation and immune responses.

GPR89A has also been shown to play a role in the regulation of cellular processes, such as cell adhesion, migration, and invasion. GPR89A has also been shown to interact with the cell adhesion molecule, E-cadherin, which is involved in the regulation of

Protein Name: G Protein-coupled Receptor 89A

The "GPR89A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPR89A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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