SMARCA4: Key Regulator of Cell Cycle and Cell Proliferation (G6597)

Target Name: SMARCA4

NCBI ID: G6597

SMARCA4

SMARCA4: Key Regulator of Cell Cycle and Cell Proliferation

SMARCA4 (BAF190A) is a protein that is expressed in various tissues of the body, including the brain, heart, and lungs. It is a key regulator of the cell cycle, and is involved in the development and maintenance of normal cell structure and function. SMARCA4 has also been shown to play a role in the regulation of cell proliferation and survival.

SMARCA4 is a member of the SMARCA family of proteins, which are known for their ability to regulate the cell cycle in a variety of cell types. The SMARCA family includes several different proteins, including SMARCA1, SMARCA2, and SMARCA3, which are expressed in various tissues of the body.

SMARCA4 is a 21-kDa protein that is expressed in the brain, heart, and lungs. It is a key regulator of the cell cycle, and is involved in the development and maintenance of normal cell structure and function. SMARCA4 helps to control the length of the G1 phase of the cell cycle, which is the phase of cell growth and preparation for cell division.

SMARCA4 is also involved in the regulation of cell proliferation and survival. It has been shown to play a role in the regulation of cell proliferation, and is involved in the inhibition of cell proliferation signaling pathways. In addition, SMARCA4 has also been shown to play a role in the regulation of cell survival, and is involved in the inhibition of cell death signaling pathways.

SMARCA4 is also a good candidate for a drug target. The SMARCA4 protein has been shown to play a role in the regulation of the cell cycle, and is involved in the development and maintenance of normal cell structure and function. As a result, SMARCA4 may be a potential drug target for the treatment of various diseases, including cancer.

In addition, SMARCA4 may also be used as a biomarker for certain diseases. The SMARCA4 protein is expressed in various tissues of the body, including the brain, heart, and lungs, and is involved in the development and maintenance of normal cell structure and function. As a result, the levels of SMARCA4 may be an indicator of the health of certain tissues, and may be used as a biomarker for certain diseases.

Overall, SMARCA4 is a protein that is expressed in various tissues of the body, and is involved in the development and maintenance of normal cell structure and function. It is also involved in the regulation of cell proliferation and survival, and may be a potential drug target and biomarker for the treatment of various diseases. Further research is needed to fully understand the role of SMARCA4 in the regulation of the cell cycle and the development and maintenance of normal cell structure and function.

Protein Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4

Functions: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity)

The "SMARCA4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SMARCA4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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