Understanding The Role of WEE1 in Cellular Signaling and Processes

Target Name: WEE1

NCBI ID: G7465

WEE1

Understanding The Role of WEE1 in Cellular Signaling and Processes

WEE1 (FLJ16446) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the WEE1 family, which is characterized by the presence of a unique C-terminus domain.

WEE1 is known for its role in the regulation of mitochondrial function and metabolism. It has been shown to interact with various cellular signaling pathways, including the TOR signaling pathway. This interaction is thought to play a role in the regulation of cellular processes such as cell growth, apoptosis, and inflammation.

WEE1 has also been shown to be involved in the regulation of ion channels, which are responsible for the flow of electrical current through cells. This is important for the proper functioning of many different cellular processes, including muscle contractions and nerve signals.

In addition to its role in cellular signaling, WEE1 has also been shown to play a role in the regulation of cellular processes related to inflammation. It has been shown to interact with several signaling pathways that are involved in the regulation of inflammation, including the NF-kappa-B signaling pathway. This interaction is thought to play a role in the regulation of processes such as inflammation, pain, and tissue repair.

WEE1 is also of interest because it has been shown to be involved in the regulation of cellular processes that are related to aging. It has been shown to interact with several pathways that are involved in the regulation of aging, including the TOR signaling pathway and the DNA damage response. This interaction is thought to play a role in the regulation of processes such as DNA repair, cell cycle progression, and stress resistance.

Despite its potential role in several different cellular processes, much research has not yet been done on WEE1 as a drug target or biomarker. This is because the molecular mechanisms that are responsible for its function are not well understood, and there is a need for further research to determine the full extent of its involvement in cellular processes.

In conclusion, WEE1 is a protein that has been shown to interact with several different signaling pathways, including the TOR signaling pathway. Its role in the regulation of mitochondrial function, ion channels, inflammation, and aging is of interest, and further research is needed to determine its potential as a drug target or biomarker.

Protein Name: WEE1 G2 Checkpoint Kinase

Functions: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation

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•   general information;
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•   expression level;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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