GGCT: A Potential Drug Target and Biomarker for Diseases (G79017)
GGCT: A Potential Drug Target and Biomarker for Diseases
Gamma-glutamylcyclotransferase (GGCT) is an enzyme located in the endoplasmic reticulum that plays a crucial role in the regulation of protein synthesis and degradation. The GGCT enzyme has been identified as a potential drug target and a biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.
GGCT is a transmembrane protein that catalyzes the transfer of the gamma-glutamyl group from its substrate to the amino acid cysteine. This transfer reaction is the first step in the biosynthesis of the protein synthesis pathway and is a critical step in the regulation of protein homeostasis. GGCT is also involved in the degradation of certain proteins, including the neurotransmitter serotonin.
Studies have suggested that GGCT is involved in the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, GGCT has been shown to be overexpressed in various types of cancer, including breast, ovarian, and prostate cancer. This increase in GGCT expression has been linked to the development of cancer-related symptoms and the poor prognosis of these diseases.
In addition to its involvement in cancer, GGCT has also been linked to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. GGCT has been shown to be overexpressed in the brains of individuals with these conditions and has been implicated in the progression of these diseases.
GGCT has also been linked to autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. These conditions involve an immune response that targets the body's own tissues and can cause chronic inflammation and damage. GGCT has been shown to be involved in the regulation of immune cell function and has been implicated in the development of these disorders.
Despite its involvement in several diseases, GGCT has not yet been studied extensively, and there is a lack of understanding of its underlying mechanisms. Further research is needed to determine the role of GGCT in disease and to develop new treatments based on this protein.
In conclusion, GGCT is an enzyme that plays a critical role in the regulation of protein synthesis and degradation. Its involvement in the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders makes it an attractive drug target and a potential biomarker. Further research is needed to fully understand the role of GGCT in disease and to develop new treatments based on this protein.
Protein Name: Gamma-glutamylcyclotransferase
Functions: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912)
The "GGCT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GGCT comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
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