PLAU: A Drug Target / Disease Biomarker (G5328)

Target Name: PLAU

NCBI ID: G5328

PLAU

PLAU: A Drug Target / Disease Biomarker

PLAU is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the PLAU family of proteins, which are known for their role in intracellular signaling. One of the key functions of PLAU is to regulate the levels of histone proteins in the nucleus of cells. Histones are small, positively charged proteins that play a structural role in organizing DNA in the nucleus of a cell. They are also involved in the regulation of gene expression and have been implicated in a wide range of cellular processes, including cell division, differentiation, and stress response.

PLAU is well-studied, and its function in intracellular signaling is well understood. It is known to play a role in the regulation of the levels of histone proteins, including histone H3, which is a key component of the nucleosome, the basic unit of chromatin. The levels of histone H3 are regulated by a variety of factors, including the levels of histone modifications, such as acetylation and methylation, and the levels ofPLAU itself.

PLAU is also involved in the regulation of the levels of other proteins, including the transcription factor TGF-β. TGF-β is a well-known protein that plays a role in the regulation of cell growth, differentiation, and survival. It is known to interact with PLAU and to regulate the levels of PLAU in the nucleus of cells.

In addition to its role in regulating the levels of histone proteins, PLAU is also thought to have other functions in intracellular signaling. For example, it is known to play a role in the regulation of the levels of proteins involved in the stress response, such as the protein heat shock protein (Hsp)70. Hsp70 is a protein that is involved in the regulation of a wide range of cellular processes, including the production of reactive oxygen species (ROS) that can damage cellular components and contribute to aging and disease. PLAU is thought to play a role in the regulation of the levels of Hsp70 in the nucleus of cells.

PLAU is also involved in the regulation of the levels of proteins involved in the cell division machinery. It is known to play a role in the regulation of the levels of the protein kinase CKX2A, which is involved in the regulation of cell division.

In conclusion, PLAU is a well-studied protein that is involved in a wide range of intracellular signaling processes. It is known to play a role in the regulation of the levels of histone proteins, including histone H3, and in the regulation of the levels of other proteins, including TGF-β and Hsp70. It is also thought to play a role in the regulation of cell division and the stress response. As a drug target or biomarker, PLAU may be a valuable target for the study of a wide range of cellular processes, including cancer, neurodegenerative diseases, and aging.

Protein Name: Plasminogen Activator, Urokinase

Functions: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin

The "PLAU Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLAU comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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