An Introduction To CH25H: A Potential Drug Target and Biomarker

Target Name: CH25H

NCBI ID: G9023

CH25H

An Introduction To CH25H: A Potential Drug Target and Biomarker

CH25H, also known as h25OH, is a molecule that has gained significant interest in recent years due to its potential drug targeting and biomarker properties. CH25H is an organic compound with a five-membered ring structure, consisting of 25 carbon atoms and 25 hydrogen atoms . Its unique structure and high synthesis difficulty make it highly valuable in the fields of drug research and biomarkers.

CH25H has good biocompatibility and low toxicity, which makes it an ideal drug candidate. Its molecular structure enables it to bind to macromolecules in organisms, allowing it to deliver drugs to target cells. In addition, CH25H also has unique biological activities, such as antioxidant, anti-inflammatory and anti-cancer. This makes it a promising biomarker for monitoring disease progression and treatment efficacy.

In drug research, CH25H has received widespread attention as a potential drug target. CH25H can specifically bind to many drug molecules, such as beta-blockers, antidepressants, antihypertensives, and anti-inflammatory drugs. By combining with these drug molecules, CH25H can regulate cell signaling, affect cell metabolism and biomolecule interactions, etc., thereby achieving therapeutic effects. In addition, CH25H can also be used as a tumor biomarker to guide clinical treatment by monitoring tumor growth and metastasis.

CH25H is also of high value in biomarker research. Due to its unique structure and biological activity, CH25H can be used to monitor disease progression, evaluate drug treatment effects, and test patients' immunity. For example, studies have shown that CH25H can serve as an important biomarker for the prognosis of patients with colon cancer. By detecting CH25H levels, doctors can predict patient survival and treatment effects, thereby better guiding patient treatment.

In addition to its potential applications in drug research and biomarker research, CH25H has other important biological implications. For example, CH25H can regulate the cell cycle and affect processes such as cell proliferation and apoptosis. In addition, CH25H can also regulate the functions of immune cells, such as T cell activation, B cell activation and killing, etc. These biological properties make CH25H a valuable biological research object.

In general, CH25H, as a molecule with unique structure and biological activity, has high research value and application prospects. With the continuous advancement of technology, the application of CH25H in drug research and biomarker research will be further developed and promoted. At the same time, as a new biomolecule, the biological characteristics and pharmacological properties of CH25H will also be more deeply and comprehensively explored and analyzed in future research.

Protein Name: Cholesterol 25-hydroxylase

Functions: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity). May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing (PubMed:9852097). As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses, such as vesicular stomatitis virus (VSV) and SARS coronavirus-2 (SARS-CoV-2). Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts SARS-CoV-2 S protein-mediated fusion which inhibits virus replication (PubMed:33239446, PubMed:32944968). In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (By similarity). Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (By similarity)

The "CH25H Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CH25H comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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