ATP6V0D1: A Potential Drug Target and Biomarker for V-ATPase Subunit D

Target Name: ATP6V0D1

NCBI ID: G9114

ATP6V0D1

ATP6V0D1: A Potential Drug Target and Biomarker for V-ATPase Subunit D

Abstract:

ATP6V0D1, also known as V-ATPase subunit D, is a protein that plays a crucial role in the function of the V-ATPase enzyme. The V-ATPase is a transmembrane protein that is involved in a variety of cellular processes, including the regulation of cell signaling pathways, DNA replication, and protein synthesis. The dysfunction of the V-ATPase has been implicated in a wide range of diseases, including cancer, neurodegenerative diseases, and respiratory disorders. In this article, we will discuss the potential drug targeting of ATP6V0D1 and its implications as a biomarker for various diseases.

Introduction:

The V-ATPase is a transmembrane protein that is composed of two subunits, ATP6V0D1 and ATP6V0D2. The subunit D, ATP6V0D1, is responsible for the catalytic activity of the V-ATPase enzyme. The V-ATPase is a critical regulator of various cellular processes, including the regulation of cell signaling pathways, DNA replication, and protein synthesis. The dysfunction of the V-ATPase has been implicated in a wide range of diseases, including cancer, neurodegenerative diseases, and respiratory disorders.

Drug Targeting of ATP6V0D1:

The potential drug targeting of ATP6V0D1 is based on its role as a protein that is involved in the regulation of cellular processes. Several studies have shown that the V-ATPase is involved in the regulation of various cellular processes, including cell signaling pathways, DNA replication, and protein synthesis. Therefore, drugs that target the V-ATPase subunit D may have a therapeutic effect on various cellular processes.

One of the potential drug targets of ATP6V0D1 is the inhibition of the V-ATPase enzyme. The inhibition of the V-ATPase enzyme can lead to the dysfunction of the cell signaling pathways, which can result in the development of various diseases. For example, the inhibition of the V-ATPase enzyme has been shown to have a therapeutic effect on cancer cells.

Another potential drug target of ATP6V0D1 is the inhibition of the DNA replication process. The DNA replication process is a critical process that is involved in the regulation of cell growth and development. The inhibition of the DNA replication process can lead to the dysfunction of the cell signaling pathways, which can result in the development of various diseases, including cancer.

Biomarker Potential of ATP6V0D1:

ATP6V0D1 is a protein that is involved in the regulation of various cellular processes. Therefore, it has the potential to serve as a biomarker for various diseases. The dysfunction of the V-ATPase enzyme has been implicated in a wide range of diseases, including cancer, neurodegenerative diseases, and respiratory disorders. Therefore, the measurement of the level of ATP6V0D1 may be a useful biomarker for the diagnosis and treatment of various diseases.

Conclusion:

In conclusion, ATP6V0D1 is a protein that is involved in the regulation of various cellular processes and has the potential to serve as a biomarker for the diagnosis and treatment of various diseases. The inhibition of the V-ATPase enzyme has been shown to have a therapeutic effect on cancer cells and the inhibition of the DNA replication process has been shown to have a therapeutic effect on various diseases. Therefore, the potential drug targeting of ATP6V0D1 is a promising area of research that may lead to the development of new therapeutic approaches for the treatment of various diseases.

Protein Name: ATPase H+ Transporting V0 Subunit D1

Functions: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002, PubMed:28296633, PubMed:30374053). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:30374053). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity)

The "ATP6V0D1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATP6V0D1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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