IST1 Gene as A Potential Drug Target for Cardiovascular Diseases

Target Name: IST1

NCBI ID: G9798

IST1

IST1 Gene as A Potential Drug Target for Cardiovascular Diseases

Sodium is an essential nutrient that plays a crucial role in various physiological processes in the human body. However, high levels of sodium can cause various health problems, including high blood pressure, heart disease, and stroke. The IST1 gene, which encodes for the IST1 protein, has been identified as a drug target or biomarker for various cardiovascular diseases, including hypertension, heart failure, and diabetes.

IST1 gene and its function

The IST1 gene encodes for a protein that is expressed in various tissues and cells in the body. The primary function of this protein is to regulate sodium levels in the body. IST1 helps to increase the body's sodium tolerance by increasing the amount of sodium that the body can absorb.

IST1 gene and hypertension

Hypertension, or high blood pressure, is a common condition that can lead to various health problems, including heart disease, stroke, and kidney damage. IST1 plays a crucial role in regulating sodium levels and has been identified as a potential drug target for hypertension.

Research has shown that IST1 gene is regulated by various factors, including blood pressure, sodium levels, and body weight. IST1 has been shown to be highly expressed in the blood vessels of individuals with hypertension, and it has been shown to play a negative role in the development of hypertension.

IST1 gene and heart failure

Heart failure is a condition that can occur due to various factors, including heart muscle damage or problems with the heart's electrical system. IST1 has been shown to be involved in the development and progression of heart failure.

Research has shown that IST1 gene is regulated by various factors, including heart failure, sodium levels, and body weight. IST1 has been shown to play a crucial role in the development and progression of heart failure by increasing the body's sodium tolerance and contributing to the thickening of heart muscle.

IST1 gene and diabetes

Diabetes is a common condition that can lead to various health problems, including cardiovascular disease, neuropathy, and kidney damage. IST1 has been shown to be involved in the development and progression of diabetes.

Research has shown that IST1 gene is regulated by various factors, including diabetes, sodium levels, and body weight. IST1 has been shown to play a negative role in the development and progression of diabetes by contributing to insulin resistance and increasing the body's sensitivity to insulin.

IST1 gene as a drug target

IST1 gene has been identified as a potential drug target for various cardiovascular diseases, including hypertension, heart failure, and diabetes. Researchers are currently studying the IST1 gene and its function to develop new treatments for these diseases.

IST1 gene therapy

There is ongoing research into using IST1 gene therapy to treat various cardiovascular diseases. Researchers are studying the IST1 gene's potential as a drug delivery system to deliver drugs directly to the IST1 gene, which could potentially reduce the risk of side effects and improve the effectiveness of the treatment.

Conclusion

IST1 gene has been identified as a potential drug target or biomarker for various cardiovascular diseases, including hypertension, heart failure, and diabetes. IST1's function is to regulate sodium levels in the body, and it has been shown to play a crucial role in the development and progression of these diseases. Further research is needed to fully understand the IST1 gene's role in these conditions and to develop new treatments.

Protein Name: IST1 Factor Associated With ESCRT-III

Functions: ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129480, PubMed:19129479). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888)

The "IST1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IST1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets