Understanding ITGAL: Potential Drug Target (G3683)

Target Name: ITGAL

NCBI ID: G3683

ITGAL

Understanding ITGAL: Potential Drug Target

ITGAL (integrin alpha-1) is a protein that is expressed in many different tissues throughout the body. It is a member of the integrin family, which is a group of transmembrane proteins that play a critical role in cell-cell and cell-extracellular matrix interactions. ITGAL is one of the proteins that is known as an alpha-1 integrin, which means that it is a subunit of the alpha-1 integrin complex that is involved in cell adhesion and migration.

The alpha-1 integrin complex is composed of four subunits: ITGAL, ITGAL3, ITGAL6, and ITGAL9. These subunits are held together by non-covalent bonds, and they are involved in various physiological processes, including cell adhesion, migration, and signaling. ITGAL is a key subunit of the alpha-1 integrin complex, and it is involved in many of the functions that are associated with this complex.

One of the key functions of ITGAL is its role in cell adhesion. Integrins are involved in the formation of tight junctions, which are specialized junctions that are found in many different types of cells, including epithelial cells, endothelial cells, and neural cells. These junctions help to maintain the integrity of the cell membrane and keep cells organized in three-dimensional space. ITGAL is involved in the formation of these junctions by interacting with the cytoplasm and the cell surface.

Another function of ITGAL is its role in cell migration. Integrins are also involved in the process of cell migration, which is the movement of cells from one location to another. ITGAL is involved in this process by interacting with the cytoskeleton and the actin cytoskeleton. These interactions help to regulate the movement of the cell and are important for the development and progression of many different types of cancer.

ITGAL is also involved in many other physiological processes, including cell signaling, cytokinesis, and inflammation. For example, ITGAL has been shown to be involved in the regulation of cell proliferation and differentiation, and it has been shown to play a role in the development and progression of many different types of cancer.

Despite the many important functions of ITGAL, little is known about this protein. There are currently no drugs that are specifically designed to target ITGAL, and there is a need for further research to understand its role in the body and its potential as a drug target.

The ITGAL gene is located on chromosome 12q24 and it encodes a protein of 114 amino acids. It is a single gene that contains a single exon. ITGAL is highly conserved and has been shown to be involved in many different signaling pathways.

ITGAL is a protein that is expressed in many different tissues throughout the body, including the liver, the kidney, the heart, and the brain. It is also found in many different types of cancer, including breast, ovarian, and colorectal cancer.

In conclusion, ITGAL is a protein that is involved in many different physiological processes and is expressed in many different tissues throughout the body. Despite its importance, little is known about this protein, and there is a need for further research to understand its role in the body and its potential as a drug target. Further studies are needed to determine the full extent of ITGAL's involvement in various physiological processes and to explore its potential as a drug target.

Protein Name: Integrin Subunit Alpha L

Functions: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590)

The "ITGAL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ITGAL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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