NFAT5 Regulates T Cell Activity (G10725)

Target Name: NFAT5

NCBI ID: G10725

NFAT5

NFAT5 Regulates T Cell Activity

NFAT5, or Nuclear Factor of Activated T Cells 5, is a protein that plays a critical role in the regulation of T cells, a type of immune cell that plays a crucial role in protecting the body against infection and disease. T cells are responsible for identifying and destroying foreign substances like viruses and bacteria, and they are a vital part of the immune system. NFAT5 helps to regulate the activity of T cells, ensuring that they are able to effectively carry out their important work without causing unnecessary harm to the body.

One of the things that makes NFAT5 so important is its role in controlling the activation and proliferation of T cells. When a T cell is first activated, NFAT5 helps to ensure that it is able to multiply and differentiate into a functional, effective immune cell. This is important because T cells have a long lifespan and are involved in a wide range of immune responses, so it is important that they are able to be controlled and directed by the immune system.

Another important function of NFAT5 is its role in regulating the production of antibodies. When a T cell is activated, it is able to produce antibodies, which are proteins that are specifically designed to recognize and neutralize the foreign substance that is causing the infection or inflammation. NFAT5 helps to regulate the production of antibodies by ensuring that the T cells are able to effectively communicate with the B cells, the cells that are responsible for producing antibodies.

In addition to its role in regulating T cell activity, NFAT5 is also involved in the regulation of cell death. When a T cell is no longer needed, NFAT5 helps to ensure that it is properly degraded and disposed of, so that the body does not have to deal with unnecessary waste. This is important because T cells have a short lifespan and are replaced by new T cells, so it is important that they are properly disposed of to ensure that the immune system is able to function properly.

Another important function of NFAT5 is its role in the regulation of the immune response. NFAT5 helps to ensure that the immune system is able to effectively respond to an infection or inflammation, by regulating the activity of T cells. This is important because an infection or inflammation can cause a lot of damage to the body if not properly treated, and T cells are the main agents for fighting off these types of harmful substances.

In conclusion, NFAT5 is a protein that plays a vital role in the regulation of T cells, ensuring that they are able to effectively carry out their important work without causing unnecessary harm to the body. NFAT5 is a potential drug target and may also be a biomarker for various diseases.

Protein Name: Nuclear Factor Of Activated T Cells 5

Functions: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076)

The "NFAT5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NFAT5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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