Target Name: RNF139
NCBI ID: G11236
Review Report on RNF139 Target / Biomarker Content of Review Report on RNF139 Target / Biomarker
RNF139
Other Name(s): RCA1 | HRCA1 | E3 ubiquitin-protein ligase RNF139 | MGC31961 | Multiple membrane spanning receptor TRC8 | multiple membrane spanning receptor TRC8 | Translocation in renal carcinoma on chromosome 8 protein | patched related protein translocated in renal cancer | Patched related protein translocated in renal cancer | TRC8 | RING-type E3 ubiquitin transferase RNF139 | translocation in renal carcinoma, chromosome 8 | ring finger protein 139 | RING finger protein 139 | translocation in renal carcinoma on chromosome 8 protein | Ring finger protein 139 | RN139_HUMAN

RNF139: A Potential Drug Target for Cancer and Neurodegenerative Diseases

RNA-Factive Nucleotide Adenylate Transporter 1 (RNF139) is a protein that plays a crucial role in the regulation of DNA replication and repair in various organisms, including humans. It is a key component of the DNA damage response and is involved in the repair of DNA double-strand breaks and the correction of base mutations. RNF139 is also involved in the regulation of gene expression and has been implicated in a variety of diseases, including cancer.

The RNA-Factive Nucleotide Adenylate Transporter 1 (RNF139) is a protein that is expressed in various tissues and cells of the body. It is a member of the RNA-protein subfamily and is composed of 215 amino acids. RNF139 is primarily localized to the endoplasmic reticulum (ER) and is also found in the cytoplasm.

RNF139 is involved in the regulation of DNA replication and repair. It is a key component of the DNA damage response and is involved in the repair of DNA double-strand breaks and the correction of base mutations. RNF139 plays a crucial role in the regulation of gene expression by ensuring that damaged DNA is properly repaired and that gene expression is properly regulated.

In addition to its role in DNA replication and repair, RNF139 is also involved in the regulation of gene expression. It has been shown to play a role in the regulation of cell cycle progression and in the development of cancer. RNF139 has also been shown to be involved in the regulation of cell survival and in the development of neurodegenerative diseases.

RNF139 is a drug target (or biomarker) of interest for a variety of diseases, including cancer. Several studies have shown that inhibiting RNF139 can have therapeutic effects in these diseases. For example, studies have shown that inhibiting RNF139 can lead to the growth inhibition and cell cycle arrest of cancer cells. In addition, studies have shown that inhibiting RNF139 can also lead to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

In conclusion, RNA-Factive Nucleotide Adenylate Transporter 1 (RNF139) is a protein that is involved in the regulation of DNA replication and repair, as well as the regulation of gene expression. It is a key component of the DNA damage response and has been implicated in a variety of diseases, including cancer. In addition to its role in DNA replication and repair, RNF139 is also involved in the regulation of gene expression and has been shown to play a role in the development of cancer and neurodegenerative diseases. As a result, RNF139 is a drug target (or biomarker) of interest for a variety of diseases and may be a useful target for the development of new therapies.

Protein Name: Ring Finger Protein 139

Functions: E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439). Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067). Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569). This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767). In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569). Required for INSIG1 ubiquitination (PubMed:20068067). May be required for EIF3 complex ubiquitination (PubMed:20068067)

The "RNF139 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF139 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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