GABARAP: A Protein Associated with GABA(A) Receptor and Potential Drug Target

Target Name: GABARAP

NCBI ID: G11337

GABARAP

GABARAP: A Protein Associated with GABA(A) Receptor and Potential Drug Target

GABARAP (GABA(A) receptor-associated protein) is a protein that is expressed in various tissues and cells in the body. It is a key regulator of the nervous system and has been implicated in a number of neurological and psychiatric disorders. In this article, we will discuss the research on GABARAP and its potential as a drug target or biomarker.

GABA is a neurotransmitter that is involved in the regulation of neural activity. It is a potent inhibitor of anxiety and depression, and is believed to have a therapeutic potential in the treatment of these disorders. The GABA(A) receptor is a G protein that is involved in the signaling of GABA. It is a seven-transmembrane protein that is expressed in various tissues and cells, including the brain. The GABA(A) receptor is thought to play a key role in the regulation of anxiety and depression, as well as other neurological and psychiatric disorders.

GABARAP is a protein that is associated with the GABA(A) receptor. It is a 12-kDa protein that is expressed in various tissues and cells, including the brain. It is a key regulator of the nervous system and is involved in the regulation of a wide range of physiological processes. GABARAP has been shown to interact with the GABA(A) receptor and is thought to play a role in the regulation of the activity of this receptor.

Research on GABARAP has focused on its potential as a drug target or biomarker. GABARAP has been shown to be involved in a number of signaling pathways that are involved in the regulation of neural activity. It has been shown to interact with a variety of molecules, including the GABA(A) receptor, neurotransmitters, and intracellular signaling molecules.

One of the potential uses of GABARAP as a drug target is its ability to modulate the activity of the GABA(A) receptor. The GABA(A) receptor is involved in the regulation of a wide range of physiological processes, including the regulation of anxiety and depression. GABARAP has been shown to interact with the GABA(A) receptor and is thought to play a role in the regulation of this receptor. This suggests that GABARAP may be a useful target for the treatment of anxiety and depression.

Another potential use of GABARAP as a drug target is its ability to modulate the activity of other signaling pathways. GABARAP has been shown to interact with a variety of molecules, including neurotransmitters and intracellular signaling molecules. This suggests that GABARAP may be a useful target for the regulation of a wide range of physiological processes.

GABARAP has also been shown to be involved in the regulation of a number of cellular processes that are important for maintaining cellular homeostasis. For example, GABARAP has been shown to play a role in the regulation of ion homeostasis, which is important for maintaining the proper levels of ions in the cells. GABARAP has also been shown to play a role in the regulation of cell volume, which is important for maintaining the proper size and shape of the cells.

In conclusion, GABARAP is a protein that is associated with the GABA(A) receptor. It is a key regulator of the nervous system and has been shown to play a role in the regulation of a wide range of physiological processes. As a result, GABARAP is a potential drug target and may be useful for the treatment of anxiety and depression. Further research is needed to fully understand the role of GABARAP in the regulation of neural activity and to determine its potential as a drug target or biomarker.

Protein Name: GABA Type A Receptor-associated Protein

Functions: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:9892355). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15169837, PubMed:20562859, PubMed:22948227). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (PubMed:25684205). Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (PubMed:25684205). Involved in apoptosis (PubMed:15977068)

The "GABARAP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GABARAP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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