TMEM199: A Transmembrane Protein of Undetermined Potential as a Drug Target or Biomarker

Target Name: TMEM199

NCBI ID: G147007

TMEM199

TMEM199: A Transmembrane Protein of Undetermined Potential as a Drug Target or Biomarker

Abstract:

TMEM199, also known as transmembrane protein 199, is a protein that is expressed in various cell types of the human body. Its function and localization have not been fully understood, but it is known to be involved in various signaling pathways. Recent studies have suggested that TMEM199 may have potential as a drug target or biomarker. This article will review the current literature on TMEM199, including its function, localization, and potential as a drug target or biomarker.

Introduction:

TMEM199 is a transmembrane protein that is expressed in various cell types of the human body. It has been shown to be involved in various signaling pathways, including the TGF-β pathway, the sonic hedgehog pathway, and the Wnt pathway. TMEM199 has also been shown to play a role in cell adhesion, migration and invasion.

In addition to its function in cell biology, TMEM199 has also been suggested as a potential drug target or biomarker. Its unique localization in the cell membrane and its involvement in various signaling pathways have led researchers to investigate its potential as a drug target.

Function and Localization:

TMEM199 is a transmembrane protein that is located at the end of the cell membrane. It consists of four domains: an extracellular domain, a transmembrane domain, an intracellular domain, and a cytoplasmic domain. The transmembrane domain is the most well-studied part of TMEM199 and is responsible for its localization to the cell membrane.

TMEM199 has been shown to localize to the outer membrane of various cell types, including epithelial, endothelial, and neural cells. It has also been shown to be involved in cell adhesion, migration and invasion.

Potential as a Drug Target:

TMEM199 has been shown to play a role in various signaling pathways, including the TGF-β pathway, the sonic hedgehog pathway, and the Wnt pathway. It is involved in the regulation of cell proliferation, cell adhesion, and cell migration.

Recent studies have suggested that TMEM199 may have potential as a drug target. For example, TMEM199 has been shown to be involved in the regulation of cell adhesion and migration, making it a potential target for drugs that can modulate these processes. Additionally, TMEM199 has has also been shown to be involved in the regulation of cell proliferation, which makes it a potential target for drugs that can inhibit cell proliferation.

Potential as a Biomarker:

TMEM199 has also been suggested as a potential biomarker for various diseases, including cancer. Its involvement in various signaling pathways and its localization to the cell membrane make it an attractive candidate for use as a biomarker.

Recent studies have shown that TMEM199 is involved in the regulation of cell adhesion and migration, which are processes that are often disrupted in cancer cells. This suggests that TMEM199 may be a useful biomarker for the detection and treatment of cancer.

Conclusion:

In conclusion, TMEM199 is a transmembrane protein that is involved in various signaling pathways. Its unique localization in the cell membrane and its involvement in cell adhesion, migration and invasion make it an attractive candidate as a potential drug target or biomarker. Further research is needed to fully understand its function and potential as a drug target or biomarker.

Protein Name: Transmembrane Protein 199

Functions: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833330)

The "TMEM199 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM199 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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