TMEM190: A Protein Involved in Brain Development and Function

Target Name: TMEM190

NCBI ID: G147744

TMEM190

Other Name(s): MDAC1 | Transmembrane protein 190 | TM190_HUMAN | transmembrane protein 190

TMEM190: A Protein Involved in Brain Development and Function

TMEM190 (MDAC1) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the transmembrane protein family and is characterized by the presence of a transmembrane domain and a cytoplasmic tail.

TMEM190 has been shown to play a role in the regulation of cellular processes that are important for brain development and function. One of the key functions of TMEM190 is its role in the development and maintenance of the blood-brain barrier, which is a specialized barrier that separates the brain from the surrounding bloodstream. This barrier is critical for the protection of the brain and allows it to function independently of the bloodstream.

In addition to its role in the blood-brain barrier, TMEM190 has also been shown to be involved in the regulation of cell signaling pathways that are important for brain development and function. For example, studies have shown that TMEM190 can interact with the protein PDGF-BB, which is a key signaling molecule that is involved in the development and maintenance of tissues in the brain.

Another function of TMEM190 is its role in the regulation of cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs. TMEM190 has been shown to play a role in the regulation of cell adhesion by interacting with the protein cadherin.

In addition to its role in the regulation of cell signaling pathways, TMEM190 has also been shown to play a role in the regulation of cellular processes that are important for the development and maintenance of tissues in the body. For example, studies have shown that TMEM190 can interact with the protein F-actin, which is involved in the regulation of cell contractility.

TMEM190 is also a potential drug target. Studies have shown that blocking the activity of TMEM190 using small interfering RNA (siRNA) can reduce the migration of cancer cells through the blood-brain barrier. This suggests that TMEM190 may be an attractive target for cancer therapies that are designed to target the brain.

In addition to its potential as a drug target, TMEM190 is also a potential biomarker for various diseases. For example, studies have shown that levels of TMEM190 have been elevated in the brains of individuals with Alzheimer's disease, which suggests that it may be an attractive biomarker for this disease.

Overall, TMEM190 is a protein that has been shown to play a role in a variety of cellular processes that are important for brain development and function. Its potential as a drug target and biomarker make it an attractive target for researchers who are working to develop new therapies for a variety of diseases.

Protein Name: Transmembrane Protein 190

The "TMEM190 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM190 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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