IL-1 Receptor (nonspecified subtype) Related Diseases

IL-1 Receptor (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Stroke, Ischemic
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism

3) Diabetes Type 2
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

4) Diabetes Type 1
Type 1 Diabetes Mellitus, also known as diabetes mellitus, insulin-dependent, is related to type 1 diabetes mellitus 12 and type 1 diabetes mellitus 5, and has symptoms including polyuria and polydipsia. An important gene associated with Type 1 Diabetes Mellitus is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are IL-9 Signaling Pathways and Immune response NFAT in immune response. The drugs Rituximab and Glipizide have been mentioned in the context of this disorder. Affiliated tissues include Bone and Pancreas, and related phenotypes are diabetes mellitus and polydipsia

5) Arthritis, Gouty
Gout, also known as gouty arthritis, is related to tubulointerstitial kidney disease, autosomal dominant, 1 and phosphoribosylpyrophosphate synthetase superactivity, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Gout is DARS2 (Aspartyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Drug ADME. The drugs Allopurinol and Febuxostat have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and skin, and related phenotypes are no effect and no effect

6) Cryopyrin-associated Periodic Syndromes
Cinca Syndrome, also known as cryopyrin-associated periodic syndrome 3, is related to cryopyrin-associated periodic syndrome and chronic meningitis, and has symptoms including recurrent fevers An important gene associated with Cinca Syndrome is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Ginseng and Rilonacept have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and bone, and related phenotypes are nausea and vomiting and increased intracranial pressure

7) Hidradenitis Suppurativa
Hidradenitis Suppurativa, also known as acne inversa, is related to dowling-degos disease and inflammatory bowel disease 1, and has symptoms including painful nodules, exanthema and pruritus. An important gene associated with Hidradenitis Suppurativa is NCSTN (Nicastrin), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Triamcinolone and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lymph node, and related phenotypes are no effect and no effect

8) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

9) Multiple Sclerosis
Multiple Sclerosis, also known as ms, is related to pediatric multiple sclerosis and autoimmune hepatitis, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Phosphorylation of CD3 and TCR zeta chains and Cell differentiation - expanded index. The drugs Acetaminophen and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube and Limb, and related phenotypes are spasticity and diplopia

10) Multiple Myeloma
Myeloma, Multiple, also known as multiple myeloma, is related to monoclonal gammopathy of uncertain significance and plasma cell neoplasm. An important gene associated with Myeloma, Multiple is LIG4 (DNA Ligase 4), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Busulfan and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are osteopenia and pathologic fracture

11) Familial Mediterranean Fever
Familial Mediterranean Fever, also known as periodic fever syndrome, is related to autoinflammation, panniculitis, and dermatosis syndrome and brucellosis, and has symptoms including abdominal pain, arthralgia and fever. An important gene associated with Familial Mediterranean Fever is MEFV (MEFV Innate Immunity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Interleukin 1 Receptor Antagonist Protein and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, b cells and kidney, and related phenotypes are nausea and vomiting and constipation

12) Still Disease
Systemic Onset Juvenile Idiopathic Arthritis, also known as systemic-onset juvenile idiopathic arthritis, is related to juvenile rheumatoid arthritis and purpura. An important gene associated with Systemic Onset Juvenile Idiopathic Arthritis is LACC1 (Laccase Domain Containing 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Adipogenesis. The drugs Prednisone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and t cells, and related phenotypes are fever and autoimmunity

13) Kawasaki Disease
Kawasaki Disease, also known as mucocutaneous lymph node syndrome, is related to exanthem and conjunctivitis, and has symptoms including fever, congestion of ocular conjunctivae and reddening of lips. An important gene associated with Kawasaki Disease is THRIL (TNF And HNRNPL Related Immunoregulatory Long Non-Coding RNA), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Immunoglobulin G and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include body, lymph node and heart, and related phenotypes are proteinuria and cheilitis

14) Macrophage Activation Syndrome
Macrophage Activation Syndrome is related to hemophagocytic lymphohistiocytosis, familial, 1 and griscelli syndrome, type 2. An important gene associated with Macrophage Activation Syndrome is PRF1 (Perforin 1), and among its related pathways/superpathways are ERK Signaling and MIF Mediated Glucocorticoid Regulation. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and bone, and related phenotypes are fever and anemia

15) Giant Cell Arteritis
Temporal Arteritis, also known as polymyalgia rheumatica, is related to myocarditis and arteritic anterior ischemic optic neuropathy, and has symptoms including back pain, exanthema and muscle cramp. An important gene associated with Temporal Arteritis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and eye, and related phenotypes are joint stiffness and fatigue

16) Pericarditis
Pericarditis is related to constrictive pericarditis and pericardial tuberculosis, and has symptoms including chest pain An important gene associated with Pericarditis is PRG4 (Proteoglycan 4), and among its related pathways/superpathways are Cytokine Signaling in Immune system and IL-9 Signaling Pathways. The drugs Coal tar and Colchicine have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related phenotypes are homeostasis/metabolism and growth/size/body region

17) Myocardial Infarction
Myocardial Infarction, also known as heart attack, is related to lipoprotein quantitative trait locus and cardiovascular system disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Myocardial Infarction is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include Bone and Limb.

18) Myocarditis
Myocarditis, also known as myocardial inflammation, is related to autoimmune myocarditis and rheumatic myocarditis. An important gene associated with Myocarditis is BAG3 (BAG Cochaperone 3), and among its related pathways/superpathways are Innate Immune System and Cardiac conduction. The drugs Abatacept and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include heart, bone marrow and t cells, and related phenotypes are no effect and no effect

19) Heart Failure
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

20) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

21) Idiopathic Pulmonary Fibrosis
Acute Interstitial Pneumonia, also known as acute interstitial pneumonitis, is related to mikulicz disease and pulmonary fibrosis, and has symptoms including dyspnea on exertion and dry cough. An important gene associated with Acute Interstitial Pneumonia is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are Disease and Innate Immune System. The drugs Nintedanib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and bone, and related phenotypes are dyspnea and respiratory failure

22) Gout
Gout, also known as gouty arthritis, is related to tubulointerstitial kidney disease, autosomal dominant, 1 and phosphoribosylpyrophosphate synthetase superactivity, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Gout is DARS2 (Aspartyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Drug ADME. The drugs Allopurinol and Febuxostat have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and skin, and related phenotypes are no effect and no effect

23) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

24) Behcet's Disease
Behcet Syndrome, also known as behcet disease, is related to vogt-koyanagi-harada disease and spondyloarthropathy 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Behcet Syndrome is MEFV (MEFV Innate Immunity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Fluocinolone acetonide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, eye and skin, and related phenotypes are nausea and vomiting and arthritis

25) Blepharitis
Blepharitis is related to blepharoconjunctivitis and keratoconjunctivitis, and has symptoms including erythema of the eyelids An important gene associated with Blepharitis is LACRT (Lacritin), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Permethrin and Fusidic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone marrow, and related phenotypes are digestive/alimentary and immune system

26) Graft-versus-host Disease
Graft-Versus-Host Disease, also known as graft-versus-host disease, susceptibility to, is related to bronchiolitis obliterans and acute graft versus host disease. An important gene associated with Graft-Versus-Host Disease is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Tacrolimus and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone marrow and t cells, and related phenotypes are elevated hepatic transaminase and skin erosion

27) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

28) Diabetic Neuropathy
Diabetic Neuropathy, also known as diabetic neuropathies, is related to microvascular complications of diabetes 3 and diabetic polyneuropathy, and has symptoms including neuralgia and sciatica. An important gene associated with Diabetic Neuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and CREB Pathway. The drugs Histamine and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and dorsal root ganglion, and related phenotypes are no effect and no effect

29) Colitis
Colitis is related to ulcerative colitis and inflammatory bowel disease 1. An important gene associated with Colitis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Magnesium citrate and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and t cells, and related phenotypes are no effect and no effect

30) Conjunctivitis, Allergic
Allergic Conjunctivitis, also known as perennial allergic conjunctivitis, is related to vernal keratoconjunctivitis and giant papillary conjunctivitis. An important gene associated with Allergic Conjunctivitis is HRH1 (Histamine Receptor H1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Hyaluronic acid and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and thymus, and related phenotypes are homeostasis/metabolism and immune system

31) Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, also known as guam disease, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 3 and frontotemporal dementia and/or amyotrophic lateral sclerosis 2, and has symptoms including tremor, bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 is TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Varenicline and Riluzole have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and brain, and related phenotypes are muscle weakness and dementia

32) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

33) Autoimmune Disease
Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and systemic lupus erythematosus. An important gene associated with Autoimmune Disease is AIS4 (Autoimmune Disease, Susceptibility To, 4), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and skin, and related phenotypes are autoimmune antibody positivity and endocrine/exocrine gland

34) Corneal Neovascularization
Corneal Neovascularization, also known as extensive superficial corneal vascularisation, is related to keratitis, hereditary and corneal disease. An important gene associated with Corneal Neovascularization is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Bevacizumab and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and bone marrow, and related phenotypes are homeostasis/metabolism and nervous system

35) Osteoarthritis
Osteoarthritis, also known as osteoarthrosis, is related to cartilage disease and exostosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are ECM proteoglycans and Extracellular matrix organization. The drugs Fentanyl and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotype is limbs/digits/tail.

36) Hypertension, Pulmonary
Pulmonary Hypertension, also known as primary pulmonary hypertension, is related to pulmonary hypertension, primary, 1 and persistent fetal circulation syndrome, and has symptoms including angina pectoris, chest pain and coughing. An important gene associated with Pulmonary Hypertension is BMPR2 (Bone Morphogenetic Protein Receptor Type 2), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and miRNAs involved in DNA damage response. The drugs Morphine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include Lung, heart and endothelial, and related phenotypes are muscle and cardiovascular system

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