Osteoarthritis
About the Disease
Osteoarthritis, also known as osteoarthrosis, is related to cartilage disease and exostosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are ECM proteoglycans and Extracellular matrix organization. The drugs Fentanyl and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotype is limbs/digits/tail.
Common Targets
G9290 | G2642 | Inositol Monophosphatase (nonspecified subtype) | G10413 | G11040 | G5243 | Phosphodiesterase (nonspecified subtype) | G7422 | G149233 | G6331 | G624 | G7078 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | G11255 | G7525 | G5168 | G5294 | G114548 | G3718 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | G8658 | G4486 | G4982 | G5028 | G3716 | G55297 | G4790 | G9578 | G6416 | G774 | G11173 | G1576 | G6714 | G249 | G596 | G3572 | G860 | Prostanoid Receptor (nonspecified subtype) | G3576 | G3791 | G80781 | G6622 | G5155 | G6097 | G1734 | G7276 | G51185 | G254251 | G11174 | G2048 | G1973 | Carbonic Anhydrase (nonspecified subtype) | G8854 | G9536 | G4157 | G5879 | G1735 | G3574 | G6768 | G7098 | G2191 | G2629 | G6697 | G3717 | G55384 | P6176 | G3553 | G3077 | G8515 | Tachykinin Receptor (nonspecified subtype) | G64084 | P16704 | G84876 | G6774 | P16513 | G407010 | G3557 | Interleukin-1 (nonspecified subtype) | G4986 | G50964 | G8483 | G6608 | G5142 | G344875 | G3551 | G1646 | G5321 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G2263 | G59341 | G1277 | G3569 | G10786 | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | G1902 | G4988 | G6093 | G2787 | Heat shock protein 90 (nonspecified subtype) | G3786 | G406947 | G695 | G727 | G1520 | G1269 | G650 | G1991 | G23765 | G3612 | G427 | Hedgehog Protein (nonspecified subtype) | Mucin (nonspecified subtype) | G406932 | G5600 | Folate Receptor (nonspecified subtype) | G3274 | G4314 | G56413 | Casein kinase I (nonspecified subtype) | G6446 | G11096 | G1636 | G4217 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | G1514 | Matrix Metalloproteinase (MMP) (nonspecified subtype) | IL-1 Receptor (nonspecified subtype) | Calcium channel (nonspecified subtype) | G4041 | G7286 | G9212 | G1111 | G1432 | G7040 | G558 | G3932 | G4595 | G10266 | G102724428 | G632 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | G842 | Protein kinase C (nonspecified subtype) | G1950 | G598 | G57396 | Fibroblast growth factor (FGF) (nonspecified subtype) | G4128 | G4321 | G415116 | G7099 | G23263 | P6058 | G7297 | G1436 | G7295 | G10110 | P19243 | G6868 | G79054 | Neurotrophic Factor (nonspecified subtype) | G1977 | G55584 | G8600 | G10267 | G6530 | G1740 | G5032 | G10320 | Opioid receptor (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | G3375 | CDK9/Cyclin T1 | G5291 | G2050 | G26118 | G4921 | G23411 | G5604 | P16176 | P34664 | G19 | G1981 | G10268 | G1268 | G22943 | Estrogen receptor (nonspecified subtype) | G7052 | G1982 | G23476 | G1490 | G440275 | Inhibitory kappaB Kinase (IKK) (nonspecified subtype) | G1859 | G5293 | G2696 | G729230 | G26354 | P11113 | DNA Topoisomerase II (nonspecified subtype) | G7114 | G1025 | G4159 | G80351 | G952 | G10749 | G51135 | G142 | G9261 | G3549 | G55830 | P5662 | G6850 | G3074 | G7442 | G5727 | G3554 | G7046 | Phospholipase A2, Cytosolic (nonspecified subtype) | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | G2147 | G3605 | P40594 | G4170 | G7498 | G857 | G904 | G140 | G4985 | G5742 | G1300 | G2833 | G7123 | G43 | G841 | G10216 | G796 | G5468 | G1452 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | G11251 | G6649 | G4914 | G2932 | Retinoid acid receptor (nonspecified subtype) | G3990 | G2224 | G25847 | G6910 | G2043 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | G10461 | G5734 | G1000 | G8792 | G10203 | G10724 | G162514 | G1491 | Aggrecanase (nonspecified subtype) | G8038 | G2166 | G3480 | G1230 | G2690 | G3630 | G112744 | G1437 | G6662 | Caspase (nonspecified subtype) | G4322 | Sodium channel (nonspecified subtype) | G3953 | G6833 | G2099 | G7301 | G5775 | G117154 | G623 | G5138 | G9507 | G7042 | G1292 | P32669 | G8672 | Mitogen-Activated Protein Kinase (nonspecified subtype) | G2260 | G836 | G2911 | G1195 | G5167 | G84444 | G2697 | G64499 | G10320 | G1969 | G4318 | P11025 | G23235 | G57105 | G9149 | G335 | Janus Kinase (nonspecified subtype) | G2908 | G5745 | G1513 | G9475 | G3552 | G4481 | G780 | G5292 | G9934 | G2317 | G57016 | G6335 | G41 | Gastric H+/K+-ATPase | G6532 | Cyclooxygenase (COX) (nonspecified subtype) | G4317 | P32821 | G27163 | G7077 | G728 | G3558 | G2548 | G50508 | G3991 | P6348 | G4067 | G4088 | G7402 | G4056 | G1508 | G117194 | G150094 | G834 | G100302124 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | G23213 | G861 | G4313 | G23245 | G799 | P32822 | G406938 | G5598 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | G23032 | G355 | P16192 | Collagenase (nonspecified subtype) | G367 | G4843 | G4233 | G7421 | G5027 | G8989 | G5743 | G1280 | Rho kinase (ROCK) (nonspecified subtype) | G4323 | G2935 | G6347 | G5136 | G29110 | P24924 | G5307 | G1141 | G4282 | G4363 | G91039 | G7043 | G7067 | G5290 | G2534 | G8200 | G1196 | G7294 | G1901 | G8714 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | G1302 | P29647 | G240 | G10495 | P16740 | G1509 | G1719 | G23387 | G2740 | G284004 | G2019 | G8639 | G9388 | G4524 | G2322 | G5732 | G339500 | G7124 | G283120 | G3293 | G3586 | G4803 | G3785 | G126014 | G983 | NADPH Oxidase (nonspecified subtype) | P32833 | G154215 | G50515
The "Target / Biomarker Review Report" is a comprehensive and customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about the Target(s) / Biomarker(s) of your choice related to Osteoarthritis, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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Spinocerebellar Ataxia | Spinocerebellar Ataxia Type 1
