Matrix Metalloproteinase (MMP) (nonspecified subtype) Related Diseases

Matrix Metalloproteinase (MMP) (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Hypophosphatasia
Hypophosphatasia, also known as phosphoethanolaminuria, is related to hypophosphatasia, childhood and hypophosphatasia, infantile, and has symptoms including seizures, waddling gait and apnea. An important gene associated with Hypophosphatasia is ALPL (Alkaline Phosphatase, Biomineralization Associated), and among its related pathways/superpathways are RhoGDI Pathway and Vitamin D receptor pathway. The drugs Hops and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and skin, and related phenotypes are bowing of the long bones and abnormality of the dentition

3) Stroke, Ischemic
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism

4) Stroke
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

5) Otitis Media
Otitis Media, also known as opsoclonus-myoclonus syndrome, is related to suppurative otitis media and chronic purulent otitis media, and has symptoms including myoclonus and ophthalmoplegia. An important gene associated with Otitis Media is A2ML1 (Alpha-2-Macroglobulin Like 1), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Halofantrine and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and breast, and related phenotypes are sleep disturbance and ataxia

6) Filariasis
Filarial Elephantiasis, also known as lymphatic filariasis, is related to loiasis and onchocerciasis, and has symptoms including chyluria An important gene associated with Filarial Elephantiasis is IL10 (Interleukin 10), and among its related pathways/superpathways are Akt Signaling and Overview of interferons-mediated signaling pathway. The drugs Doxycycline and Petrolatum have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and testis, and related phenotypes are lymphadenopathy and predominantly lower limb lymphedema

7) Papulopustular Rosacea
Rosacea, also known as erythematotelangiectatic rosacea, is related to telangiectasis and acne, and has symptoms including exanthema and pruritus. An important gene associated with Rosacea is CAMP (Cathelicidin Antimicrobial Peptide), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Metronidazole and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and pituitary, and related phenotypes are no effect and no effect

8) Coronary Artery Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

9) Atherosclerosis
Atherosclerosis Susceptibility, also known as atherosclerosis, is related to cerebral atherosclerosis and generalized atherosclerosis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Atherosclerosis Susceptibility is ATHS (Atherosclerosis Susceptibility (Lipoprotein Associated)), and among its related pathways/superpathways are "Plasma lipoprotein assembly, remodeling, and clearance" and Interleukin-4 and Interleukin-13 signaling. The drugs Enalaprilat and Enalapril have been mentioned in the context of this disorder. Affiliated tissues include Heart, and related phenotypes are hypertriglyceridemia and myocardial infarction

10) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

11) Multiple Sclerosis
Multiple Sclerosis, also known as ms, is related to pediatric multiple sclerosis and autoimmune hepatitis, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Phosphorylation of CD3 and TCR zeta chains and Cell differentiation - expanded index. The drugs Acetaminophen and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube and Limb, and related phenotypes are spasticity and diplopia

12) Myocardial Infarction
Myocardial Infarction, also known as heart attack, is related to lipoprotein quantitative trait locus and cardiovascular system disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Myocardial Infarction is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include Bone and Limb.

13) Heart Failure
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

14) Contact Dermatitis
Contact Dermatitis, also known as contact dermatitis/eczema, is related to irritant dermatitis and nickel allergic contact dermatitis, and has symptoms including exanthema and pruritus. An important gene associated with Contact Dermatitis is IL31 (Interleukin 31), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clobetasol and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lymph node, and related phenotypes are homeostasis/metabolism and immune system

15) Amyloidosis
Amyloidosis, also known as amyloid disease, is related to amyloidosis, hereditary, transthyretin-related and immunoglobulin light chain amyloidosis. An important gene associated with Amyloidosis is TTR (Transthyretin), and among its related pathways/superpathways are Innate Immune System and Metabolism of proteins. The drugs Citalopram and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related phenotypes are no effect and no effect

16) Ulcerative Colitis
Inflammatory Bowel Disease 1, also known as inflammatory bowel disease 1, is related to inflammatory bowel disease 19 and inflammatory bowel disease 17, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Inflammatory Bowel Disease 1 is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Magnesium citrate and Prucalopride have been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and bone, and related phenotypes are growth delay and abdominal pain

17) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

18) Anthrax
Anthrax Disease, also known as anthrax, is related to oropharyngeal anthrax and inhalation anthrax, and has symptoms including skin ulcer, nausea and poor appetite. An important gene associated with Anthrax Disease is ANTXR1 (ANTXR Cell Adhesion Molecule 1), and among its related pathways/superpathways are Disease and MIF Mediated Glucocorticoid Regulation. The drugs Promethazine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, lung lymph nodes and gastrointestinal tract, and related phenotypes are no effect and no effect

19) Periodontitis
Periodontitis, also known as chronic pericementitis, is related to periodontitis, chronic and periodontitis, aggressive, 1, and has symptoms including leukorrhea and purulent discharge. An important gene associated with Periodontitis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Sodium fluoride and Menthol have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are homeostasis/metabolism and immune system

20) Atopic Dermatitis
Dermatitis, Atopic, also known as atopic dermatitis, is related to allergic disease and dermatitis, atopic, 3, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis, Atopic is FLG (Filaggrin), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Cytokine Signaling in Immune system. The drugs Zinc oxide and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related phenotypes are cataract and ichthyosis

21) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

22) Cancer, Prostate
Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and prostate disease, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Breast cancer pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node, and related phenotypes are prostate cancer and neoplasm

23) Cancer, Lung
Lung Cancer, also known as non-small cell lung carcinoma, is related to lung cancer susceptibility 3 and small cell cancer of the lung, and has symptoms including cough, chest discomfort and weight loss. An important gene associated with Lung Cancer is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Pemetrexed and Erlotinib have been mentioned in the context of this disorder. Affiliated tissues include lung, lungs and brain, and related phenotypes are lung adenocarcinoma and alveolar cell carcinoma

24) Cataract
Cataract, also known as cataracts, is related to senile cataract and cataract 1, multiple types. An important gene associated with Cataract is CRYBB3 (Crystallin Beta B3), and among its related pathways/superpathways is 1q21.1 copy number variation syndrome. The drugs Cyclopentolate and Atropine have been mentioned in the context of this disorder. Affiliated tissues include Eye, endothelial and cortex, and related phenotype is vision/eye.

25) Blepharitis
Blepharitis is related to blepharoconjunctivitis and keratoconjunctivitis, and has symptoms including erythema of the eyelids An important gene associated with Blepharitis is LACRT (Lacritin), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Permethrin and Fusidic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone marrow, and related phenotypes are digestive/alimentary and immune system

26) Neurofibromatosis
Neurofibromatosis, also known as neurofibromatoses, is related to acoustic neuroma and neurofibromatosis-noonan syndrome, and has symptoms including back pain, headache and pain. An important gene associated with Neurofibromatosis is NF1 (Neurofibromin 1), and among its related pathways/superpathways are Signal Transduction and Disease. The drugs Lidocaine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and bone, and related phenotypes are Decreased viability and Decreased viability

27) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

28) Acne
Acne, also known as acne vulgaris, is related to sapho syndrome and hidradenitis suppurativa, and has symptoms including exanthema and pruritus. An important gene associated with Acne is NCSTN (Nicastrin), and among its related pathways/superpathways are Innate Immune System and Prolactin Signaling. The drugs Calcipotriol and Adapalene have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and thyroid, and related phenotypes are no effect and no effect

29) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

30) Diabetic Macular Edema
Diabetic Macular Edema is related to vitreous detachment and retinal detachment. An important gene associated with Diabetic Macular Edema is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Dipivefrin and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are homeostasis/metabolism and nervous system

31) Systemic Lupus Erythematosus
Systemic Lupus Erythematosus, also known as lupus nephritis, is related to lupus erythematosus and autoimmune disease, and has symptoms including exanthema, pruritus and lupus-like rash. An important gene associated with Systemic Lupus Erythematosus is TREX1 (Three Prime Repair Exonuclease 1), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, bone marrow and skin, and related phenotypes are lupus nephritis and arthritis

32) Rosacea
Rosacea, also known as erythematotelangiectatic rosacea, is related to telangiectasis and acne, and has symptoms including exanthema and pruritus. An important gene associated with Rosacea is CAMP (Cathelicidin Antimicrobial Peptide), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Metronidazole and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and pituitary, and related phenotypes are no effect and no effect

33) Sarcoidosis
Sarcoidosis 2, also known as sarcoidosis, susceptibility to, 2, is related to blau syndrome and neurosarcoidosis, and has symptoms including coughing and snoring. An important gene associated with Sarcoidosis 2 is BTNL2 (Butyrophilin Like 2). The drugs Azathioprine and Pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include lung, spleen and lymph node, and related phenotypes are bronchiectasis and pleural effusion

34) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

35) Pneumonia, Bacterial
Bacterial Pneumonia, also known as bronchopneumonia due to bacteria other than s. pneumoniae and h. influenzae, is related to klebsiella pneumonia and mycoplasma pneumoniae pneumonia. An important gene associated with Bacterial Pneumonia is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clindamycin and Cilastatin have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone marrow, and related phenotypes are no effect and no effect

36) Retinopathy, Diabetic
Microvascular Complications of Diabetes 5, also known as diabetic retinopathy, is related to microvascular complications of diabetes 1 and type 1 diabetes mellitus. An important gene associated with Microvascular Complications of Diabetes 5 is PON1 (Paraoxonase 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are homeostasis/metabolism and cardiovascular system

37) Corneal Ulcer
Corneal Ulcer, also known as ulcerative keratitis, is related to conjunctivitis and pyoderma. An important gene associated with Corneal Ulcer is NGF (Nerve Growth Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Amphotericin B and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and endothelial, and related phenotypes are homeostasis/metabolism and immune system

38) Hereditary Hemorrhagic Telangiectasia
Telangiectasia, Hereditary Hemorrhagic, Type 1, also known as orw disease, is related to juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome and pulmonary hypertension, primary, 1, and has symptoms including cyanosis, dyspnea and seizures. An important gene associated with Telangiectasia, Hereditary Hemorrhagic, Type 1 is ENG (Endoglin), and among its related pathways/superpathways are TGF-beta Signaling Pathways and ALK1 signaling events. The drugs Bevacizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and brain, and related phenotypes are telangiectasia of the skin and hemoptysis

39) Osteoarthritis
Osteoarthritis, also known as osteoarthrosis, is related to cartilage disease and exostosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are ECM proteoglycans and Extracellular matrix organization. The drugs Fentanyl and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotype is limbs/digits/tail.

40) Osteoporosis
Bone Mineral Density Quantitative Trait Locus 8, also known as osteoporosis, is related to osteoporosis and bone mineral density quantitative trait locus 15, and has symptoms including angina pectoris, back pain and muscle cramp. An important gene associated with Bone Mineral Density Quantitative Trait Locus 8 is BMND8 (Bone Mineral Density Quantiative Trait Locus 8). The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord.

41) Macular Degeneration
Macular Degeneration, Age-Related, 1, also known as macular degeneration, is related to macular degeneration, age-related, 4 and retinoschisis 1, x-linked, juvenile, and has symptoms including vision loss, angina pectoris and tremor. An important gene associated with Macular Degeneration, Age-Related, 1 is HMCN1 (Hemicentin 1), and among its related pathways/superpathways is Complement cascade. The drugs Bevacizumab and Verteporfin have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are macular hemorrhage and macular degeneration

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