Transforming growth factor beta (nonspecified subtype) Related Diseases

Transforming growth factor beta (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Metabolic Diseases
3-Hydroxyacyl-Coa Dehydrogenase Deficiency, also known as hadh deficiency, is related to long-chain 3-hydroxyacyl-coa dehydrogenase deficiency and hyperinsulinemic hypoglycemia, familial, 4, and has symptoms including emaciation An important gene associated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency is HADH (Hydroxyacyl-CoA Dehydrogenase). The drugs Naloxone and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and skeletal muscle, and related phenotypes are feeding difficulties in infancy and growth delay

3) Arteriosclerosis
Arteriosclerosis, also known as arteriosclerotic vascular disease, is related to arteriosclerosis obliterans and aortic atherosclerosis, and has symptoms including angina pectoris An important gene associated with Arteriosclerosis is HS3ST1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 1), and among its related pathways/superpathways are Metabolism and Extracellular matrix organization. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and smooth muscle, and related phenotypes are Increased free cholesterol and homeostasis/metabolism

4) Thalassemia, Beta
Beta-Thalassemia, also known as beta thalassemia, is related to thrombocytopenia with beta-thalassemia, x-linked and hemoglobin lepore-beta-thalassemia syndrome. An important gene associated with Beta-Thalassemia is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. The drugs Busulfan and Metformin have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and bone, and related phenotypes are splenomegaly and pallor

5) Multiple Sclerosis
Multiple Sclerosis, also known as ms, is related to pediatric multiple sclerosis and autoimmune hepatitis, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Phosphorylation of CD3 and TCR zeta chains and Cell differentiation - expanded index. The drugs Acetaminophen and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube and Limb, and related phenotypes are spasticity and diplopia

6) Multiple Myeloma
Myeloma, Multiple, also known as multiple myeloma, is related to monoclonal gammopathy of uncertain significance and plasma cell neoplasm. An important gene associated with Myeloma, Multiple is LIG4 (DNA Ligase 4), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Busulfan and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are osteopenia and pathologic fracture

7) Pneumoconiosis
Anthracosis, also known as black lung, is related to baritosis and bronchitis. An important gene associated with Anthracosis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Pirfenidone and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

8) Focal Segmental Glomerulosclerosis
Focal Segmental Glomerulosclerosis, also known as familial idiopathic steroid-resistant nephrotic syndrome, is related to focal segmental glomerulosclerosis 2 and focal segmental glomerulosclerosis 5. An important gene associated with Focal Segmental Glomerulosclerosis is NPHS1 (NPHS1 Adhesion Molecule, Nephrin), and among its related pathways/superpathways are Cell junction organization and Nephrotic syndrome. The drugs Dapagliflozin and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include Kidney, bone marrow and bone, and related phenotypes are no effect and no effect

9) Heart Failure
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

10) Chronic Myeloid Leukemia
Leukemia, Chronic Myeloid, also known as chronic myelogenous leukemia, is related to atypical chronic myeloid leukemia, bcr-abl1 negative and juvenile myelomonocytic leukemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia, Chronic Myeloid is ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways are Overview of interferons-mediated signaling pathway and VEGF Pathway (Tocris). The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related phenotypes are myeloproliferative disorder and splenomegaly

11) Diamond-Blackfan Anemia
Diamond-Blackfan Anemia, also known as congenital pure red cell aplasia, is related to diamond-blackfan anemia 1 and diamond-blackfan anemia 10. An important gene associated with Diamond-Blackfan Anemia is RPS19 (Ribosomal Protein S19), and among its related pathways/superpathways are Metabolism of proteins and Metabolism. The drugs Deferasirox and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and myeloid, and related phenotypes are pure red cell aplasia and elevated red cell adenosine deaminase level

12) Duchenne Muscular Dystrophy
Muscular Dystrophy, Duchenne Type, also known as duchenne muscular dystrophy, is related to muscular dystrophy, becker type and facioscapulohumeral muscular dystrophy 1, and has symptoms including waddling gait and weakness. An important gene associated with Muscular Dystrophy, Duchenne Type is DMD (Dystrophin), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involvement in the immune response in sepsis. The drugs Carvedilol and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Umbilical Cord, and related phenotypes are scoliosis and respiratory insufficiency

13) Lymphoma
Lymphosarcoma, also known as lymphoma, diffuse, is related to lymphoma, non-hodgkin, familial and lymphoma, hodgkin, classic. An important gene associated with Lymphosarcoma is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are Direct p53 effectors and Interleukin-4 and Interleukin-13 signaling. The drugs Crofelemer and Aprepitant have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and myeloid.

14) Idiopathic Pulmonary Fibrosis
Acute Interstitial Pneumonia, also known as acute interstitial pneumonitis, is related to mikulicz disease and pulmonary fibrosis, and has symptoms including dyspnea on exertion and dry cough. An important gene associated with Acute Interstitial Pneumonia is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are Disease and Innate Immune System. The drugs Nintedanib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and bone, and related phenotypes are dyspnea and respiratory failure

15) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

16) Cancer, Colon
Colorectal Cancer, also known as colon cancer, is related to lynch syndrome and colonic benign neoplasm, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Colorectal Cancer is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Disease and ERK Signaling. The drugs Tramadol and Ferrous fumarate have been mentioned in the context of this disorder. Affiliated tissues include colon, rectum and liver, and related phenotypes are renal cell carcinoma and neoplasm of the stomach

17) Carcinoma, Squamous Cell
Squamous Cell Carcinoma, also known as carcinoma, squamous cell, is related to squamous cell carcinoma, head and neck and esophageal cancer. An important gene associated with Squamous Cell Carcinoma is DDR2 (Discoidin Domain Receptor Tyrosine Kinase 2). The drugs Petrolatum and Mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and tongue.

18) Neurofibromatosis
Neurofibromatosis, also known as neurofibromatoses, is related to acoustic neuroma and neurofibromatosis-noonan syndrome, and has symptoms including back pain, headache and pain. An important gene associated with Neurofibromatosis is NF1 (Neurofibromin 1), and among its related pathways/superpathways are Signal Transduction and Disease. The drugs Lidocaine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and bone, and related phenotypes are Decreased viability and Decreased viability

19) Diabetic Nephropathy
Microvascular Complications of Diabetes 2, also known as microvascular complications of diabetes, susceptibility to, 2, is related to microvascular complications of diabetes 3 and background diabetic retinopathy. An important gene associated with Microvascular Complications of Diabetes 2 is EPO (Erythropoietin). The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and retina.

20) Fibrosis
Fibrosis of Extraocular Muscles, Congenital, 1, also known as fibrosis of extraocular muscles, congenital, 3b, is related to moebius syndrome and fibrosis of extraocular muscles, congenital, 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Fibrosis of Extraocular Muscles, Congenital, 1 is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Vesicle-mediated transport. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone marrow, and related phenotypes are esotropia and exotropia

21) Muscle Wasting
Muscular Atrophy, also known as muscle wasting, is related to spinal muscular atrophy and spinal and bulbar muscular atrophy, x-linked 1, and has symptoms including muscular fasciculation, muscle cramp and spasm. An important gene associated with Muscular Atrophy is SMCHD1 (Structural Maintenance Of Chromosomes Flexible Hinge Domain Containing 1), and among its related pathways/superpathways is SARS-CoV-2 modulates host translation machinery. The drugs Acetaminophen and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, spinal cord and bone marrow, and related phenotypes are nervous system and homeostasis/metabolism

22) Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, also known as guam disease, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 3 and frontotemporal dementia and/or amyotrophic lateral sclerosis 2, and has symptoms including tremor, bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 is TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Varenicline and Riluzole have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and brain, and related phenotypes are muscle weakness and dementia

23) Liver Failure
Infantile Liver Failure Syndrome 1, also known as acute infantile liver failure-multisystemic involvement syndrome, is related to infantile liver failure syndrome and liver failure, infantile, transient, and has symptoms including seizures An important gene associated with Infantile Liver Failure Syndrome 1 is LARS1 (Leucyl-TRNA Synthetase 1), and among its related pathways/superpathways are Regulation of expression of SLITs and ROBOs and tRNA Aminoacylation. The drugs Entecavir and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and brain, and related phenotypes are frontal bossing and sensorineural hearing impairment

24) Cirrhosis
Liver Cirrhosis, also known as cirrhosis, is related to alcoholic liver cirrhosis and primary biliary cholangitis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Cirrhosis is FARSB (Phenylalanyl-TRNA Synthetase Subunit Beta), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Lung fibrosis. The drugs Racivir and Propofol have been mentioned in the context of this disorder. Affiliated tissues include Bone and Blood.

25) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

26) Lung Diseases
Lung Disease, also known as lung diseases, is related to interstitial lung disease and interstitial lung disease 2, and has symptoms including apnea, coughing and dyspnea. An important gene associated with Lung Disease is SFTPC (Surfactant Protein C), and among its related pathways/superpathways are Metabolism of proteins and Innate Immune System. The drugs Guaifenesin and Cathine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and heart, and related phenotypes are homeostasis/metabolism and immune system

27) Alopecia
Alopecia is related to alopecia universalis congenita and alopecia-mental retardation syndrome 1, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia is SASH1 (SAM And SH3 Domain Containing 1), and among its related pathways/superpathways are Direct p53 effectors and Validated transcriptional targets of TAp63 isoforms. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include Hair, and related phenotypes are no effect and no effect

28) Anemia
Deficiency Anemia, also known as anemia, is related to iron deficiency anemia and diamond-blackfan anemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Deficiency Anemia is HBA2 (Hemoglobin Subunit Alpha 2), and among its related pathways/superpathways are Cellular responses to stimuli and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Iron protein succinylate and Proguanil have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, kidney and heart, and related phenotypes are homeostasis/metabolism and liver/biliary system

29) Hermansky-Pudlak Syndrome
Hermansky-Pudlak Syndrome, also known as hps, is related to hermansky-pudlak syndrome 2 and hermansky-pudlak syndrome 5, and has symptoms including abdominal pain An important gene associated with Hermansky-Pudlak Syndrome is HPS6 (HPS6 Biogenesis Of Lysosomal Organelles Complex 2 Subunit 3), and among its related pathways/superpathways are Vesicle-mediated transport and trans-Golgi Network Vesicle Budding. The drugs Pirfenidone and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and lung, and related phenotypes are nystagmus and immunodeficiency

30) Interstitial Lung Diseases
Interstitial Lung Disease, also known as ild, is related to interstitial pneumonitis, desquamative, familial and rheumatoid arthritis interstitial lung disease, and has symptoms including shortness of breath, coughing and hemoptysis. An important gene associated with Interstitial Lung Disease is INPP5E (Inositol Polyphosphate-5-Phosphatase E), and among its related pathways/superpathways are Innate Immune System and Metabolism of proteins. The drugs Prednisone and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and skeletal muscle, and related phenotypes are homeostasis/metabolism and neoplasm

31) Marfan Syndrome
Marfan Syndrome, also known as mfs, is related to neonatal marfan syndrome and loeys-dietz syndrome 2. An important gene associated with Marfan Syndrome is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Perindopril and Verapamil have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and eye, and related phenotypes are pectus carinatum and pes planus

32) Osteoporosis, Postmenopausal
Osteoporosis, also known as postmenopausal osteoporosis, is related to osteoporosis, juvenile and bone mineral density quantitative trait locus 15, and has symptoms including angina pectoris, back pain and muscle cramp. An important gene associated with Osteoporosis is COL1A1 (Collagen Type I Alpha 1 Chain), and among its related pathways/superpathways are Breast cancer pathway and Vitamin D receptor pathway. The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include Bone, and related phenotypes are osteoporosis and homeostasis/metabolism

33) Myelodysplasia
Myelodysplastic Syndrome, also known as myelodysplastic syndromes, is related to leukemia, acute myeloid and juvenile myelomonocytic leukemia. An important gene associated with Myelodysplastic Syndrome is TET2 (Tet Methylcytosine Dioxygenase 2), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Posaconazole and Micafungin have been mentioned in the context of this disorder. Affiliated tissues include Placenta and Umbilical Cord, and related phenotypes are myelodysplasia and neoplasm

34) Myelofibrosis
Myelofibrosis, also known as primary myelofibrosis, is related to acute megakaryocytic leukemia and thrombocytosis. An important gene associated with Myelofibrosis is MPL (MPL Proto-Oncogene, Thrombopoietin Receptor), and among its related pathways/superpathways are TGF-Beta Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Panobinostat and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, myeloid and bone, and related phenotypes are fatigue and anemia

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