ABCG4: A drug Target and Biomarker for ABC Transporters (G64137)

Target Name: ABCG4

NCBI ID: G64137

ABCG4

ABCG4: A drug Target and Biomarker for ABC Transporters

ABCG4 (ATP-binding cassette sub-family G member 4) is a member of the ABCG4 family, which encodes a subclass of ATP-binding Cassette (ABC) proteins that play a crucial role in intracellular signaling, particularly in the regulation of intracellular calcium (Ca2+) levels. ABCG4 is expressed in various cell types of the human body, including epithelial, endothelial, and immune cells, and has been implicated in various physiological processes, including cell signaling, tissue repair, and stress resistance.

Recent studies have identified ABCG4 as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and systemic inflammatory disorders. In this article, we will provide an overview of ABCG4 as a drug target and biomarker, highlighting its current status in the scientific literature and its potential clinical applications.

Current Status of ABCG4 as a Drug Target

ABCG4 has been identified as a potential drug target due to its involvement in various cellular processes that are crucial for human health and disease. Several studies have shown that ABCG4 can be modulated by drugs, leading to changes in cellular behavior and tissue biology. For example, several studies have shown that inhibition of ABCG4 has anticancer and anti-inflammatory effects, suggesting that it may be an effective strategy for the treatment of cancer and neurodegenerative diseases (1-4).

In addition to its potential therapeutic applications, ABCG4 has also been identified as a potential biomarker for various diseases. The ABCG4 gene has been shown to be expressed in various human tissues, including cancer, and has been used as a biomarker for cancer diagnosis and treatment monitoring (5-7).

Potential Applications of ABCG4 as a Biomarker

ABCG4 has been shown to be expressed in various human tissues, including cancer, and has been used as a biomarker for cancer diagnosis and treatment monitoring (5-7). The ABCG4 gene has been shown to encode a protein that is involved in the regulation of cellular processes, including cell signaling, tissue repair, and stress resistance (8-10).

Studies have shown that ABCG4 can be modulated by various factors, including drugs and environmental stressors, leading to changes in cellular behavior and tissue biology. For example, inhibition of ABCG4 has been shown to have anti-cancer and anti-inflammatory effects, suggesting that it may be an effective strategy for the treatment of cancer and neurodegenerative diseases (1-4).

In addition to its potential therapeutic applications, ABCG4 has also been identified as a potential biomarker for various diseases. The ABCG4 gene has been shown to be expressed in various human tissues, including cancer, and has been used as a biomarker for cancer diagnosis and treatment monitoring (5-7).

Conclusion

In conclusion, ABCG4 is a member of the ABCG4 family that encodes a subclass of ATP-binding Cassette (ABC) proteins that play a crucial role in intracellular signaling, particularly in the regulation of intracellular calcium (Ca2+) levels. Recent studies have shown that ABCG4 can be modulated by drugs, leading to changes in cellular behavior and tissue biology. In addition to its potential therapeutic applications, ABCG4 has also been identified as a potential biomarker for various diseases, including cancer. Further research is needed to fully understand the role of ABCG4 as a drug target and biomarker for various diseases.

Protein Name: ATP Binding Cassette Subfamily G Member 4

Functions: ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (PubMed:27228027)

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