ABHD6: Catalyzing The Hydrolysis of Triacylglycerols (G57406)

Target Name: ABHD6

NCBI ID: G57406

ABHD6

ABHD6: Catalyzing The Hydrolysis of Triacylglycerols

The Abhydrolase domain containing 6 (ABHD6) protein is a member of the superfamily of lipases, which are a group of enzymes involved in the hydrolysis of fatty acids. ABHD6 is a transcript variant of the ABHD6 gene, which is located on chromosome 11p15.2. The ABHD6 protein is expressed in various tissues and cells of the body and is involved in the metabolism of various lipids, including triacylglycerols, which are a common type of lipid found in adipose tissue.

The ABHD6 protein is characterized by its ability to catalyze the hydrolysis of triacylglycerols to produce fatty acids and water. This reaction occurs through a concerted mechanism that involves the transfer of a phosphate group from the substrate to the catalytic center of the enzyme. The resulting fatty acids are then released from the enzyme as a mixture of fatty acids and water.

The ABHD6 protein has been shown to play a role in the regulation of various biological processes, including metabolism, inflammation, and autophagy. For example, studies have shown that ABHD6 is involved in the metabolism of triacylglycerols, which are a major source of energy in adipose tissue. The encoded by ABHD6 gene has been shown to be involved in the metabolism of triacylglycerols to produce fatty acids and water.

Additionally, ABHD6 is also known to be involved in the regulation of inflammation and autophagy. Studies have shown that ABHD6 is regulated by various signaling pathways, including TGF-β and NF-kappa-B signaling pathways. This regulation is important for the proper functioning of the immune system and for the regulation of cellular processes that are involved in inflammation and autophagy.

ABHD6 has also been shown to play a role in the regulation of cellular processes that are involved in cell signaling and cell death. Studies have shown that ABHD6 is regulated by various signaling pathways, including TGF-β, NF-kappa-B, and PI3K/AKT signaling pathways. This regulation is important for the proper functioning of cells and for the regulation of cellular processes that are involved in cell signaling and cell death.

Furthermore, ABHD6 is also known to be involved in the regulation of various biological processes that are involved in metabolism and cell signaling. Studies have shown that ABHD6 is regulated by various signaling pathways, including TGF-β, NF-kappa-B, and PI3K/AKT signaling pathways. This regulation is important for the proper functioning of cells and for the regulation of cellular processes that are involved in metabolism and cell signaling.

In conclusion, the ABHD6 protein is a transcript variant of the ABHD6 gene that is involved in the regulation of various biological processes, including metabolism, inflammation, and autophagy. The encoded by ABHD6 gene has been shown to play a role in the metabolism of triacylglycerols, the regulation of cellular processes that are involved in inflammation and autophagy, and the regulation of cellular processes that are involved in cell signaling and cell death. Further research is needed to fully understand the role of ABHD6 in the regulation of various biological processes and to develop potential therapeutic approaches for the treatment of diseases associated with the aberrant function of ABHD6.

Protein Name: Abhydrolase Domain Containing 6, Acylglycerol Lipase

Functions: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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