EXTL1: A Potential Drug Target for Glycosaminoglycans and Cellular Processes

Target Name: EXTL1

NCBI ID: G2134

EXTL1

Other Name(s): Alpha-N-acetylglucosaminyltransferase II glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase | Multiple exostosis-like protein | EXTL1_HUMAN | exostosin like glycosyltransferase 1 | Exostosin like glycosyltransferase 1 | MGC70794 | Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase | Alpha-N-acetylglucosaminyltransferase II | Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase | exostoses (multiple)-like 1 | Glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase | Exostosin-like 1 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase | glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase | exostosin-L | multiple exostosis-like protein | EXTL | OTTHUMP00000008700 | alpha-N-acetylglucosaminyltransferase II | Exostosin-L

EXTL1: A Potential Drug Target for Glycosaminoglycans and Cellular Processes

Alpha-N-acetylglucosaminyltransferase II (EXTL1) is a enzyme involved in the metabolism of glycosaminoglycans, which are a type of carbohydrate found in various biological tissues. Glycosaminoglycans are involved in many different cellular processes, including cell signaling, tissue repair, and inflammation. TheEXTL1 enzyme is involved in the transfer of the acetyl group from the N-acetylglucosamine molecule to the alpha-1,4-N-acetylglucosaminyl group.

EXTL1 is a critical enzyme for the biosynthesis of many different glycosaminoglycans, including the major glycosaminoglycan involved in tissue repair and inflammation, decorin. It is also involved in the biosynthesis of other glycosaminoglycans, including heparan sulfate and chondroitin sulfate, which are important in connective tissue growth and repair.

EXTL1 is also involved in the metabolism of some intracellular signaling molecules, including platelet-derived growth factor (PDGF), which is involved in cell signaling and tissue repair. TheEXTL1 enzyme has also been shown to play a role in the regulation of cell adhesion, as well as in the development and progression of certain diseases.

As a drug target

TheEXTL1 enzyme has been identified as a potential drug target for a variety of diseases. One of the main reasons for this is the involvement of EXTL1 in the biosynthesis of many different glycosaminoglycans, which are involved in various cellular processes. This means that any drug that can inhibit EXTL1 activity could potentially have a wide range of potential applications.

For example, EXTL1 has been shown to play a role in the development and progression of certain types of cancer, including breast and ovarian cancer. In addition, EXTL1 has also been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Another potential application of EXTL1 as a drug target is its role in the regulation of cell adhesion. EXTL1 has been shown to play a role in the regulation of cell-cell adhesion, which is important for the development and maintenance of tissues and organs. This means that any drug that can inhibit EXTL1 activity in these processes could potentially be useful in treating a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential as a drug target, EXTL1 has also been shown to be involved in the regulation of other cellular processes, including cell signaling, DNA replication, and metabolism. This suggests that it could potentially have a wide range of potential applications in a variety of diseases.

Conclusion

EXTL1 is an important enzyme involved in the metabolism of glycosaminoglycans, which are involved in various cellular processes. As a drug target, EXTL1 has the potential to be used to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of EXTL1 in these processes and to develop effective treatments.

Protein Name: Exostosin Like Glycosyltransferase 1

Functions: Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS) (PubMed:11390981). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity) (PubMed:11390981). Appears to lack GlcNAcT I and GlcAT-II activities (PubMed:11390981)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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