EYA3: A Potential Drug Target and Biomarker for Eye-related Disorders

Target Name: EYA3

NCBI ID: G2140

EYA3

EYA3: A Potential Drug Target and Biomarker for Eye-related Disorders

Abstract:

EYA3, the eye-absent homolog 3 (ISOFORM A), is a gene that encodes a protein involved in the development and maintenance of the retina. The loss of EYA3 has been implicated in a range of eye-related disorders, including blindness, cataracts, and age-related macular degeneration. This article discusses the potential implications of EYA3 as a drug target and biomarker for these disorders.

Introduction:

EYA3, also known as eyes absent homolog 3 (ISOFORM A), is a gene located on chromosome X that encodes a protein involved in the development and maintenance of the retina. The retina is a critical part of the eye, responsible for collecting light, transmitting it to the brain, and providing sensory information. The loss of EYA3 has been implicated in a range of eye-related disorders, including blindness, cataracts, and age-related macular degeneration (AMD).

Potential Implications of EYA3 as a Drug Target:

EYA3 has been identified as a potential drug target for a range of eye-related disorders, including blindness, cataracts, and AMD. Its role in these disorders makes it an attractive target for drug development.

First, EYA3 has been shown to regulate the growth and differentiation of photoreceptor cells, which are responsible for collecting light and transmitting it to the brain. The loss of EYA3 has been linked to the decreased sensitivity to light that is observed in individuals with certain inherited eye disorders. By targeting EYA3 and increasing its expression, it may be possible to treat these disorders.

Second, EYA3 has also been shown to play a role in the development and progression of cataracts. Cataracts are a common age-related disorder that can cause blindness by clouding the lens that focuses light. EYA3 has been shown to regulate the production of lens proteins, which are important in the development and maintenance of the lens. By targeting EYA3 and increasing its expression, it may be possible to treat cataracts.

Third, EYA3 has also been implicated in the development and progression of AMD, a common age-related disorder that can cause blindness. EYA3 has been shown to regulate the production of retinal pigment, which is important in the development and maintenance of the retina. By targeting EYA3 and increasing its expression, it may be possible to treat AMD.

Potential Implications of EYA3 as a Biomarker:

In addition to its potential as a drug target, EYA3 has also been identified as a potential biomarker for a range of eye-related disorders. The loss of EYA3 has been observed in individuals with certain inherited eye disorders, including the X-linked Alport syndrome, which is characterized by the progressive loss of vision and hearing in males.

EYA3 has also been shown to be decreased in individuals with age-related macular degeneration (AMD), a common age-related disorder that can cause blindness. AMD is characterized by the progressive loss of the macular, a part of the retina responsible for providing central vision. The loss of EYA3 has been shown to be associated with an increased risk of AMD.

In addition to its association with eye disorders, EYA3 has also been shown to be involved in the development and maintenance of the retina. Its absence has been linked to the decreased sensitivity to light that is observed in individuals with certain inherited eye disorders.

Conclusion:

In conclusion, EYA3 is a gene that has

Protein Name: EYA Transcriptional Coactivator And Phosphatase 3

Functions: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye

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