GGA2: A GPCR Protein with Unique Interaction and Signaling Properties
GGA2: A GPCR Protein with Unique Interaction and Signaling Properties
GGA2 (FLJ20966) is a protein that is expressed in a variety of tissues, including the brain, heart, and kidneys. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling. GGA2 is unique among its family members because of its unique structure and the specific way it interacts with its ligands.
GGA2 is a 194-amino acid protein that has a molecular weight of 21 kDa. It consists of an extracellular domain that is responsible for its ability to interact with ligands, a transmembrane region, and an intracellular tail. The extracellular domain of GGA2 is made up of a single alpha-helical structure that is responsible for its ability to interact with ligands. This domain contains a critical region that is involved in the formation of the beta-sheet structure that is present in many GPCR proteins.
The transmembrane region of GGA2 is made up of a single transmembrane 伪-helical structure. This region is responsible for the protein's ability to interact with its ligands and for its overall stability. The transmembrane region also contains a unique feature that is not found in other GPCR proteins, that is, a double aromatic loop (DAL) region. This region is thought to play a key role in the regulation of GGA2's activity and is involved in the formation of the protein's stable interactions with its ligands.
The intracellular tail of GGA2 is made up of a single amino acid residue and is responsible for the protein's ability to interact with intracellular signaling molecules. This region is known as the N-terminus and is located at the end of the protein. Like the transmembrane and extracellular regions of GGA2, the intracellular tail region is also involved in the regulation of GGA2's activity and is thought to play a key role in its intracellular signaling functions.
GGA2 is a GPCR protein that is expressed in a variety of tissues, including the brain, heart, and kidneys. It is a key regulator of many cellular processes, including cell signaling, neurotransmission, and blood pressure. GGA2 is also involved in the regulation of pain perception and in the development of certain diseases, such as cancer.
One of the most promising aspects of GGA2 is its potential as a drug target. GPA2 has been shown to play a key role in a variety of cellular processes, including cell signaling, neurotransmission, and blood pressure. GPA2 is also involved in the regulation of pain perception and in the development of certain diseases, such as cancer.
GPA2 has also been shown to be a good biomarker for several diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. This is because GPA2 is often overexpressed or mutated in these diseases, which can be used as targets for new drugs.
In conclusion, GGA2 (FLJ20966) is a unique and highly-regulated protein that is involved in a variety of cellular processes. Its unique structure, including the double aromatic loop (DAL) region, makes it a valuable target for new drugs. GGA2 is also a valuable biomarker for several diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Further research is needed to fully understand the role of GGA2 in these diseases and to develop new treatments.
Protein Name: Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2
Functions: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712)
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More Common Targets
GGA3 | GGACT | GGCT | GGCX | GGH | GGN | GGNBP1 | GGNBP2 | GGPS1 | GGT1 | GGT2P | GGT3P | GGT5 | GGT6 | GGT7 | GGT8P | GGTA1 | GGTLC1 | GGTLC2 | GGTLC3 | GH1 | GH2 | GHDC | GHITM | GHR | GHRH | GHRHR | GHRL | GHRLOS | GHSR | GID4 | GID8 | GIGYF1 | GIGYF2 | GIHCG | GIMAP1 | GIMAP1-GIMAP5 | GIMAP2 | GIMAP3P | GIMAP4 | GIMAP5 | GIMAP6 | GIMAP7 | GIMAP8 | GIMD1 | GIN1 | GINM1 | GINS complex | GINS1 | GINS2 | GINS3 | GINS4 | GIP | GIPC1 | GIPC2 | GIPC3 | GIPR | GIT1 | GIT2 | GJA1 | GJA10 | GJA1P1 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJA9-MYCBP | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GK | GK2 | GK3 | GK5 | GKAP1 | GKN1 | GKN2 | GKN3P | GLA | GLB1 | GLB1L | GLB1L2 | GLB1L3 | GLC1C | GLCCI1 | GLCCI1-DT | GLCE | GLDC | GLDN
