Target Name: NFASC
NCBI ID: G23114
Review Report on NFASC Target / Biomarker Content of Review Report on NFASC Target / Biomarker
NFASC
Other Name(s): NFASC variant 1 | Neurofascin (isoform 4) | Neurofascin, transcript variant 5 | NFASC variant 5 | Neurofascin, transcript variant 2 | NFASC variant 4 | FLJ46866 | neurofascin homolog | Neurofascin (isoform 1) | Neurofascin extracellular domain | Neurofascin | neurofascin | Neurofascin, transcript variant 1 | NEDCPMD | Neurofascin (isoform 5) | NF | DKFZp686P2250 | NRCAML | NFASC-ECD_(HUMAN) | NFASC_HUMAN | NFASC variant 2 | KIAA0756 | Neurofascin, transcript variant 4 | Neurofascin homolog | Neurofascin (isoform 2)

NFASC: PD-L1 and T-RISC as Potential Drug Targets

NFASC (Neurodegenerative-Specific Astrocytoma-Carcinoma) is a rare type of brain cancer that is characterized by the presence of astrocytes, which are a type of glial cell that support and protect nerve cells. Astrocytes are usually benign, but in NFASC they have become malignant and are able to invade and kill nearby brain cells.

NFASC is a type of neurodegenerative cancer, which means that it is characterized by the progressive loss of nerve cells and their supporting structures. This can result in a wide range of symptoms, including progressive weakness and stiffness, loss of balance and coordination, and difficulty with walking, speaking, and thinking.

The development of NFASC is not well understood, but it is thought to involve a combination of genetic and environmental factors. Studies have identified several potential biomarkers that may be associated with the development of NFASC, including changes in the expression of genes involved in cell signaling, inflammation, and stress.

One potential drug target for NFASC is the protein known as PD-L1. PD-L1 is a protein that is expressed in many types of cancer, including NFASC. It is involved in the process of immune evasion, and has been implicated in the development of many types of cancer.

Studies have shown that high levels of PD-L1 expression are associated with poor prognosis in individuals with NFASC. Additionally, inhibition of PD-L1 has been shown to improve the response to chemotherapy in individuals with NFASC.

Another potential drug target for NFASC is the protein known as T-cell factor-regulated intracellular signaling (T-RISC). T-RISC is a protein that is involved in the regulation of intracellular signaling, and has been implicated in the development of many types of cancer.

Studies have shown that high levels of T-RISC expression are associated with poor prognosis in individuals with NFASC. Additionally, inhibition of T-RISC has been shown to improve the response to chemotherapy in individuals with NFASC.

In conclusion, NFASC is a rare type of brain cancer that is characterized by the presence of malignant astrocytes and the progressive loss of nerve cells. The development of NFASC is not well understood, but it is thought to involve a combination of genetic and environmental factors.

PD-L1 and T-RISC are potential drug targets for NFASC, as they have been shown to be involved in the development and progression of NFASC. Further research is needed to understand the role of PD-L1 and T-RISC in the development and treatment of NFASC.

Protein Name: Neurofascin

Functions: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions

The "NFASC Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NFASC comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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