PGRMC1: Regulator of Protein Homeostasis and Cellular Processes

Target Name: PGRMC1

NCBI ID: G10857

PGRMC1

PGRMC1: Regulator of Protein Homeostasis and Cellular Processes

PGRMC1 (Proteasome Generator Regulatory Protein-C) is a protein that plays a crucial role in the regulation of protein homeostasis, which is the process by which cells remove and recycle damaged or unnecessary proteins. PGRMC1 is a key regulator of the proteasome, which is a complex machinery that breaks down and recycles proteins in the cell.

The proteasome is responsible for removing damaged or dysfunctional proteins, as well as recycling them when they are no longer needed. This process is essential for maintaining cellular homeostasis and is dynamically regulated by a variety of factors, including PGRMC1.

PGRC1 is a member of the PGRMC family of proteins, which includes PGRMC1, PGRMC2, PGRMC3, and PGRMC4. These proteins share a conserved catalytic core and a common regulatory mechanism, which involves the formation of a covalent complex with a specific protein-protein interaction companion.

The PGRMC1 protein is composed of 194 amino acid residues and has a calculated molecular mass of 21 kDa. It is expressed in a variety of cell types, including human tissues and organs, and is involved in the regulation of protein homeostasis.

One of the key functions of PGRMC1 is its role as a regulator of the proteasome. PGRMC1 forms a covalent complex with the protein PSMB2, which is a key component of the proteasome. This complex creates a stable interface between PGRMC1 and PSMB2, allowing PGRMC1 to regulate the activity of the proteasome.

PGRC1 is involved in the regulation of several cellular processes, including cell growth, apoptosis, and inflammation. It has been shown to play a role in the regulation of cell cycle progression, and has been implicated in the development and progression of several diseases, including cancer.

In addition to its role in the regulation of the proteasome, PGRMC1 is also involved in the regulation of protein stability and degradation. It has been shown to interact with several proteins that are involved in the regulation of protein stability, including the protein known as TrpM2.

TrpM2 is a non-coding RNA molecule that has been shown to play a role in the regulation of protein stability and degradation. It is composed of 58 amino acid residues and is expressed in a variety of cell types, including human cells.

PGRC1 has been shown to interact with TrpM2 and with several other proteins that are involved in the regulation of protein stability and degradation. This suggests that PGRMC1 may be a useful drug target or biomarker for the development of therapies aimed at modulating protein homeostasis and the regulation of cellular processes.

In conclusion, PGRMC1 is a protein that plays a crucial role in the regulation of protein homeostasis and the development of cellular processes. It is involved in the regulation of the proteasome, protein stability, and degradation, and has been implicated in the development and progression of several diseases. Therefore, PGRMC1 may be a useful drug target or biomarker for the development of therapies aimed at modulating protein homeostasis and the regulation of cellular processes.

Protein Name: Progesterone Receptor Membrane Component 1

Functions: Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036)

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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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