PGRMC2: A Potential Drug Target for Cell Adhesion, Migration, and Survival

Target Name: PGRMC2

NCBI ID: G10424

PGRMC2

PGRMC2: A Potential Drug Target for Cell Adhesion, Migration, and Survival

PGRMC2 (Perforin-Glycoprotein-Receptor-Complex) is a protein that is expressed in various tissues throughout the body, including the brain. It is a member of the perforin family of proteins, which are involved in the regulation of cell death and homeostasis. PGRMC2 has been identified as a potential drug target and has been shown to play a role in a variety of biological processes, including neurodegenerative diseases, ischemia, and inflammation.

The perforin family of proteins is characterized by the presence of a perforin domain, which is a conserved region that is involved in the formation of perforins. Perforins are known to be involved in the regulation of cell death, as they can interact with various cellular signaling pathways and play a role in the formation of the endoplasmic reticulum. PGRMC2 is a member of the glycoprotein subfamily, which is characterized by the presence of a transmembrane region and a cytoplasmic tail.

PGRC2 has been shown to play a role in a variety of biological processes, including the regulation of cell adhesion, migration, and survival. For example, PGRMC2 has been shown to interact with the protein PDGFR-??, which is involved in the regulation of cell adhesion and migration. This interaction between PGRMC2 and PDGFR-?? has been shown to play a role in the regulation of cancer cell growth and metastasis.

PGRC2 has also been shown to be involved in the regulation of cell survival. For example, PGRMC2 has been shown to interact with the protein Bcl-2, which is involved in the regulation of cell survival and apoptosis. This interaction between PGRMC2 and Bcl-2 has been shown to play a role in the regulation of cancer cell survival and the efficacy of anti-cancer drugs.

PGRC2 has also been shown to play a role in the regulation of inflammation. For example, PGRMC2 has been shown to interact with the protein NF-kappa-B, which is involved in the regulation of inflammation and immune responses. This interaction between PGRMC2 and NF-kappa-B has been shown to play a role in the regulation of inflammation and the efficacy of anti-inflammatory drugs.

In conclusion, PGRMC2 is a protein that is involved in a variety of biological processes, including cell adhesion, migration, and survival. Its interaction with other proteins, including PDGFR-??, Bcl-2, and NF-kappa-B, suggests that it may be a potential drug target for a variety of diseases, including cancer and neurodegenerative diseases. Further research is needed to fully understand the role of PGRMC2 in these processes and to determine its potential as a drug target.

Protein Name: Progesterone Receptor Membrane Component 2

Functions: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity)

The "PGRMC2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PGRMC2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets