PHF19: A Protein Potential Drug Target Or Biomarker (G26147)

Target Name: PHF19

NCBI ID: G26147

PHF19

PHF19: A Protein Potential Drug Target Or Biomarker

PHF19, also known as tudor domain containing 19B, is a protein that is expressed in various tissues throughout the body. It is a member of the PHF1 family, which includes several similar proteins that play a role in the regulation of cell division and differentiation. One of the most interesting aspects of PHF19 is its potential as a drug target or biomarker.

The discovery of PHF19 and its related proteins began in the late 1990s, when researchers identified a family of proteins that were expressed in a variety of tissues, including brain, heart, and muscle. These proteins were called PHF1, PHF2, and PHF3, and they were found to be involved in the regulation of cell division and differentiation.

Since then, researchers have been studying the PHF1 family and have identified several different proteins that are involved in the regulation of cell division and differentiation. These proteins include PHF19, PHF20, PHF21, and PHF22.

PHF19 is a protein that is expressed in a variety of tissues throughout the body, including the brain, heart, and muscle. It is a member of the PHF1 family and is involved in the regulation of cell division and differentiation.

One of the most interesting aspects of PHF19 is its potential as a drug target or biomarker. Researchers have identified several potential drug targets for PHF19, including those that are involved in the regulation of cell division and differentiation.

One of the potential drug targets for PHF19 is the protein p21, which is a transcription factor that is involved in the regulation of cell division and differentiation. p21 is a negative regulator of the PHF19 gene and is thought to play a role in the inhibition of PHF19-mediated cell division.

Another potential drug target for PHF19 is the protein p53, which is a transcription factor that is involved in the regulation of cell division and differentiation. p53 is a positive regulator of the PHF19 gene and is thought to play a role in the activation of PHF19- mediated cell division.

Research has also identified several potential biomarkers for PHF19, including the protein PHF19 itself and the PHF19-associated protein, which is involved in the regulation of cell division and differentiation. These biomarkers may be useful for the diagnosis and monitoring of PHF19-related diseases.

In conclusion, PHF19 is a protein that is expressed in various tissues throughout the body and is involved in the regulation of cell division and differentiation. Its potential as a drug target or biomarker is currently being studied by researchers, and several potential drug targets and biomarkers have been identified for PHF19. Further research is needed to fully understand the role of PHF19 in the regulation of cell division and differentiation and to develop effective treatments for PHF19-related diseases.

Protein Name: PHD Finger Protein 19

Functions: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:23104054, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832)

The "PHF19 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHF19 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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