NPHP4: A Protein Targeted By Several Diseases (G261734)

Target Name: NPHP4

NCBI ID: G261734

NPHP4

NPHP4: A Protein Targeted By Several Diseases

NPHP4, or Nephrocystin-4 (isoform c), is a protein that is expressed in the kidney and is known for its role in the regulation of water and electrolyte balance in the body. The NPHP4 gene has been identified as a drug potential target for several diseases, including diabetes, heart failure, and liver disease.

One of the unique aspects of NPHP4 is its structure. NPHP4 is a 21-kDa protein that consists of a single polypeptide chain. It has a calculated molecular weight of 11.4 kDa and a calculated pI of 6.9. NPHP4 is expressed in the kidney and has been shown to localize to the interstitial space, which is a space between cells and tissue in the body. This localization is important because it suggests that NPHP4 may play a role in the regulation of the interstitial space, which is involved in several physiological processes, including inflammation, pain, and temperature regulation.

In addition to its localization, NPHP4 has several other properties that make it an attractive drug target. For example, it is a protein that is targeted by several autoimmune diseases, including diabetes and heart failure. It is also a protein that is involved in the regulation of ion balance in the body, which is important for maintaining the normal function of the body's cells and tissues.

NPHP4 has also been shown to play a role in several diseases that are associated with inflammation. For example, studies have shown that NPHP4 is expressed in the tissues of individuals with rheumatoid arthritis, a type of autoimmune disease. Additionally, NPHP4 has been shown to be involved in the regulation of cytokine activity, which is the production of pro-inflammatory molecules. This suggests that NPHP4 may play a role in the regulation of inflammation and the development of inflammatory diseases.

Another potential mechanism by which NPHP4 may be involved in the development of diseases is its role in the regulation of the interstitial space. As mentioned earlier, the interstitial space is involved in several physiological processes, including inflammation, pain, and temperature regulation. NPHP4 has has been shown to localize to the interstitial space and to play a role in regulating the ion balance in this space. This suggests that NPHP4 may be involved in the regulation of these processes and the development of diseases that are associated with changes in the interstitial space.

In conclusion, NPHP4 is a protein that has several unique properties that make it an attractive drug target. Its localization to the interstitial space, its involvement in the regulation of ion balance and cytokine activity, and its involvement in the regulation of the interstitial space make NPHP4 a potential target for several diseases. Further research is needed to fully understand the role of NPHP4 in these diseases and to develop effective treatments.

Protein Name: Nephrocystin 4

Functions: Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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