Target Name: NPIPB5
NCBI ID: G100132247
Review Report on NPIPB5 Target / Biomarker Content of Review Report on NPIPB5 Target / Biomarker
NPIPB5
Other Name(s): Nuclear pore complex interacting protein family member B5, transcript variant 4 | nuclear pore complex interacting protein related | nuclear pore complex interacting protein family member | Putative NPIP-like protein LOC100132247 | NPIB5_HUMAN | Nuclear pore complex-interacting protein family member B5 | NPIPB5 variant 4 | nuclear pore complex interacting protein related gene | nuclear pore complex interacting protein family member B5

NPIPB5: A Potential Drug Target and Biomarker

Non-protein intracellular binding protein 5 (NPIPB5) is a protein that is expressed in various cell types of the human body. It is a member of the NPIPB family, which includes several similar proteins that play a crucial role in intracellular signaling and protein-protein interactions.NPIPB5 has been identified as a potential drug target and biomarker due to its unique structure, expression patterns, and functions in various physiological processes.

NPIPB5's Unique Structure and Expression Patterns

NPIPB5 is a 144 amino acid protein that has a unique structure. It consists of a 152 amino acid N-terminus, a 21 amino acid transmembrane region, and a 60 amino acid C-terminus. The protein has a split N-terminus, which is unique in that it contains a 24 amino acid extension that is specific to NPIPB5. This extension is involved in the protein's stability and functions as an intracellular signaling molecule.

NPIPB5 is expressed in various cell types of the human body, including neurons, muscle cells, and immune cells. Its expression patterns vary depending on the cell type and the developmental stage of the organism. In neurons, NPIPB5 is mainly expressed in the dendrites and the cell body, while in muscle cells it is mainly expressed in the sarcolemma and the myofibrils.

NPIPB5's Functions in Intracellular Signaling

NPIPB5 is involved in intracellular signaling by regulating the activity of various signaling pathways. One of its functions is to regulate the activity of the tyrosine kinase pathway, which is involved in the regulation of cell growth, differentiation, and survival. Additionally, NPIPB5 is involved in the regulation of the PI3K/Akt signaling pathway, which is involved in the regulation of cell survival and metabolism.

NPIPB5's Potential as a Drug Target

The unique structure and expression patterns of NPIPB5 make it an attractive drug target. Its split N-terminus and the 24 amino acid extension are involved in its stability and function as an intracellular signaling molecule. Therefore, small molecules that can modulate its activity or interact with its specificity may have a great impact on various cellular processes.

NPIPB5 has been identified as a potential drug target by various studies. For example, researchers have shown that inhibitors of the tyrosine kinase pathway can suppress the growth and survival of cancer cells, which suggests that NPIPB5 may be a useful target for cancer treatment. Additionally, studies have shown that NPIPB5 is involved in the regulation of cell survival and metabolism, which may make it a potential target for diseases that are characterized by cellular dysfunction and death.

NPIPB5's Potential as a Biomarker

NPIPB5 has also been identified as a potential biomarker for various diseases. Its unique structure and expression patterns make it an attractive target for diagnostic assays. For example, researchers have shown that NPIPB5 is involved in the regulation of cell death, which may be a useful biomarker for diseases characterized by cellular dysfunction and death.

In conclusion, NPIPB5 is a unique protein that has a crucial role in intracellular signaling and protein-protein interactions. Its split N-terminus and the 24 amino acid extension make it an attractive target for small molecules that can modulate its activity or interact with its specificity. Additionally, its unique structure and expression patterns make it an attractive candidate for diagnostic assays. These properties make NPIPB5 a potential drug target and biomarker for various diseases.

Protein Name: Nuclear Pore Complex Interacting Protein Family Member B5

The "NPIPB5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NPIPB5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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