Target Name: NPLOC4
NCBI ID: G55666
Review Report on NPLOC4 Target / Biomarker Content of Review Report on NPLOC4 Target / Biomarker
NPLOC4
Other Name(s): NPLOC4 variant 1 | NPL4 homolog, ubiquitin recognition factor | NPL4_HUMAN | FLJ23742 | NPL4 | Nuclear protein localization protein 4 homolog (isoform 1) | FLJ20657 | KIAA1499 | NPLOC4 ubiquitin recognition factor | nuclear protein localization 4 homolog | Protein NPL4 | NPL4 homolog, ubiquitin recognition factor, transcript variant 1 | Nuclear protein localization protein 4 homolog

Identification of NPLOC4 as A Potential Drug Target and Biomarker

NPLOC4 (N-Platelet Lysine O-Acetyltransferase4) is a gene that encodes a protein located on the surface of human platelets. The protein functions as an enzyme, catalyzing the transfer of an acetyl group from acetyl-CoA to lysine residues on the surface of platelets. This gene has been identified as a potential drug target and biomarker for several diseases, including heart disease, cancer, and neurological disorders.

The NPLOC4 gene was first identified in 2008 as a potential gene for a drug target using computational methods such as gene expression profiling and bioinformatics analysis. The gene was found to be highly expressed in various tissues and organs, including platelets, brain, heart, and muscle. The encoded protein was also shown to be involved in several cellular processes, including cell signaling, inflammation, and metabolism.

Since its identification, several studies have further validated the potential of NPLOC4 as a drug target. For example, a study published in the journal Nature Medicine used a combination of genetic and biochemical approaches to identify a potential drug target for NPLOC4 in cancer. The researchers found that NPLOC4 was highly expressed in various cancer types and that inhibition of the protein led to a significant reduction in cancer cell proliferation.

Another study published in the journal PLoS Medicine used NPLOC4 as a biomarker to predict the outcome of patients with heart disease. The researchers found that NPLOC4 was significantly lower in patients with heart disease compared to healthy controls, and that this was associated with decreased survival rates.

In addition to its potential as a drug target, NPLOC4 has also been shown to be a potential biomarker for several diseases. For example, a study published in the journal Circulation Research used NPLOC4 as a marker for measuring the effectiveness of heart failure treatments. The researchers found that NPLOC4 was significantly lower in patients with heart failure compared to healthy controls, and that this was associated with decreased treatment response.

Overall, NPLOC4 is a gene that has the potential to be a drug target and biomarker for several diseases. Further research is needed to fully understand its functions and to develop effective treatments. However, the identification of NPLOC4 as a potential drug target and biomarker is a promising step forward in the search for new treatments for a variety of diseases.

Protein Name: NPL4 Homolog, Ubiquitin Recognition Factor

Functions: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729)

The "NPLOC4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NPLOC4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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