Target Name: NPM1
NCBI ID: G4869
Review Report on NPM1 Target / Biomarker Content of Review Report on NPM1 Target / Biomarker
NPM1
Other Name(s): nucleophosmin/nucleoplasmin family, member 1 | Nucleophosmin (isoform 2) | Testicular tissue protein Li 128 | Nucleophosmin 1 (isoform 1) | Nucleophosmin (nucleolar phosphoprotein B23, numatrin) | Nucleophosmin 1, transcript variant 1 | Nucleolar phosphoprotein B23 | NPM1 variant 2 | B23 | Nucleophosmin | Nucleophosmin (isoform 3) | NPM | Nucleophosmin/nucleoplasmin family, member 1 | NPM_HUMAN | Nucleophosmin 1, transcript variant 3 | nucleolar protein NO38 | Nucleophosmin (isoform 1) | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | NPM1 variant 1 | Nucleolar protein NO38 | nucleophosmin 1 | testicular tissue protein Li 128 | Nucleophosmin 1, transcript variant 2 | Numatrin | NPM1 variant 3

Understanding NPM1: Potential Drug Targets and Biomarkers

NPM1, or nucleophosmin/nucleoplasmin family member 1, is a protein that plays a critical role in the structure and function of chromosomes. It is a key component of the nucleosome, which is the basic unit of DNA that is replicated and passed down from one generation to the next. NPM1 is also involved in the regulation of DNA replication and repair, and it has been linked to a number of important cellular processes.

Despite its importance, NPM1 is not well understood, and there are limited research studies on its role in biology. However, its potential as a drug target or biomarker has generated a lot of interest in recent years.

One of the main reasons for the lack of understanding of NPM1 is its complex structure. NPM1 is a protein that contains multiple domains, including a N-terminal domain, a central domain, and a C-terminal domain. a critical conserved sequence that is involved in the formation of nucleosomes, while the C-terminal domain contains a unique farnesylated cysteine 鈥嬧?媟esidue that is involved in the regulation of DNA replication.

While the structure of NPM1 has been studied extensively, there is still much that is not known about its function. One of the key challenges in understanding NPM1 is its regulation. NPM1 is regulated by a number of different factors, including the Ku70 protein, which is a negative regulator of DNA replication. Ku70 works by binding to the N-terminal domain of NPM1 and preventing it from forming nucleosomes.

While Ku70 is a well-studied protein, its regulation by NPM1 is not well understood. Some researchers have suggested that Ku70 may work by inhibiting the formation of nucleosomes, while others have suggested that it may be involved in the stimulation of NPM1 function.

Another challenge in understanding NPM1 is its role in cancer. NPM1 is often overexpressed in cancer cells, and its regulation by Ku70 may be a potential therapeutic target. However, it is not clear how NPM1 function is altered in cancer, or how a drug that inhibits its regulation could be effective.

Despite these challenges, research studies on NPM1 have identified several important cellular processes that are involved in its regulation. For example, NPM1 is involved in the regulation of DNA replication, and it has been shown to play a role in the maintenance of genomic stability. NPM1 is also involved in the regulation of cell cycle progression, and it has been shown to play a role in the G1/S transition that occurs at the end of the cell cycle.

In addition to its role in cellular processes, NPM1 has also been shown to be a potential drug target. Several studies have identified potential NPM1-targeting agents, including small molecules, peptides, and antibodies. These agents have been shown to interact with NPM1 and to induce a range of cellular responses, including the inhibition of DNA replication and the inhibition of cell cycle progression.

While the development of NPM1-targeting agents is an important step in the study of NPM1, it is also important to consider the potential consequences of these agents. For example, the inhibition of DNA replication by NPM1-targeting agents could have important implications for cancer treatment, as it could potentially inhibit the growth of cancer cells. On the other hand, the inhibition of cell cycle progression by NPM1-targeting agents could have implications for the treatment of certain types of cancer, as it could potentially inhibit the rapid growth and division of cancer cells.

In conclusion, NPM1 is a protein that plays a critical role in the structure and function of chromosomes, and it is a key component of the nucleosome. Despite its importance, the regulation of NPM1 is not well understood, and there are limited research studies on its role in biology. However, its potential as a drug target or biomarker has generated a lot of interest in recent years, and further research is needed to fully understand its function and potential as

Protein Name: Nucleophosmin 1

Functions: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity)

The "NPM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NPM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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