Target Name: NPNT
NCBI ID: G255743
Review Report on NPNT Target / Biomarker Content of Review Report on NPNT Target / Biomarker
NPNT
Other Name(s): Nephronectin (isoform B) | Nephronectin (isoform A) | Nephronectin | Nephronectin (isoform D) | EGFL6L | Nephronectin precursor (isoform 1) | Nephronectin, transcript variant 1 | Nephronectin, transcript variant 4 | NPNT_HUMAN | POEM | NPNT variant 1 | Preosteoblast EGF-like repeat protein with MAM domain | Protein EGFL6-like | NPNT variant 4 | preosteoblast EGF-like repeat protein with MAM domain | NPNT variant 2 | nephronectin | Nephronectin, transcript variant 2

NPNT: A Potential Drug Target and Biomarker for Kidney Disease

Kidney disease is a leading cause of morbidity and mortality worldwide, with an estimated 50 million people affected in the United States alone. Chronic kidney disease (CKD) is the most common form of kidney disease and is characterized by a decline in kidney function over time. The development of certain diseases, such as diabetes and hypertension, can increase the risk of developing CKD. Currently, there are limited treatment options available for the prevention and treatment of kidney disease, and there is a significant need for new, effective approaches to diagnose and treat these conditions.

Nephronectin (ISOform B) is a protein that is expressed in the urine and blood of individuals with kidney disease. It has been shown to have a number of potential functions in the kidneys, including the regulation of inflammation, blood vessel growth, and urine formation. In addition, nephronectin has also been shown to play a role in the development and progression of certain types of kidney disease.

Potential Therapeutic Applications

One of the key potential therapeutic applications for nephronectin is its potential as a drug target. By targeting nephronectin with small molecules or antibodies, it may be possible to treat a variety of kidney diseases, including diabetes-related kidney disease, hypertension-related kidney disease, and other forms of kidney disease.

One of the ways that nephronectin could be targeted is through its role in the regulation of inflammation in the kidneys. Chronic kidney disease is often associated with inflammation, and treatments that target inflammation may have a potential therapeutic benefit for kidney disease. By targeting nephronectin, it may be possible to reduce inflammation in the kidneys, which could potentially slow the progression of kidney disease.

Another potential therapeutic application for nephronectin is its role in the regulation of blood vessel growth in the kidneys. The kidneys rely on a network of blood vessels to deliver oxygen and nutrients to the cells that rely on them. Chronic kidney disease is often associated with changes in the size and structure of these blood vessels, which can lead to a decline in kidney function. By targeting nephronectin, it may be possible to stimulate the growth and function of blood vessels in the kidneys, which could potentially improve kidney function.

In addition to its potential therapeutic applications, nephronectin has also been shown to be a potential biomarker for kidney disease. The urine and blood of individuals with kidney disease often contain elevated levels of nephronectin, and this may be an indicator of the severity of the disease. By measuring the levels of nephronectin in the urine and blood, it may be possible to diagnose kidney disease at an early stage, when treatment is most effective.

Current Research and Treatment

While there is currently no treatment available that specifically targets nephronectin, research is being conducted to investigate its potential as a drug target and biomarker for kidney disease. Studies have shown that nephronectin can be effectively targeted with small molecules and antibodies, and that these treatments have the potential to improve kidney function in individuals with chronic kidney disease.

In addition to its potential therapeutic applications, nephronectin also has the potential to serve as a biomarker for kidney disease. Studies have shown that the levels of nephronectin in the urine and blood of individuals with kidney disease are often elevated, and this may be an indicator of the severity of the disease. By measuring the levels of nephronectin in the urine and blood, it may be possible to diagnose kidney disease at an early stage, when treatment is most effective.

Conclusion

Nephronectin is a protein that is expressed in the urine and blood of individuals with kidney disease. It has been shown to have a number of potential functions in the kidneys, including the regulation of inflammation, blood vessel growth, and urine formation. In addition, nephronectin has also been shown to play a role in

Protein Name: Nephronectin

Functions: Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity)

The "NPNT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NPNT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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NPPA | NPPA-AS1 | NPPB | NPPC | NPR1 | NPR2 | NPR3 | NPRL2 | NPRL3 | NPS | NPSR1 | NPSR1-AS1 | NPTN | NPTN-IT1 | NPTX1 | NPTX2 | NPTXR | NPVF | NPW | NPY | NPY1R | NPY2R | NPY4R | NPY4R2 | NPY5R | NPY6R | NQO1 | NQO2 | NR0B1 | NR0B2 | NR1D1 | NR1D2 | NR1H2 | NR1H3 | NR1H4 | NR1I2 | NR1I3 | NR2C1 | NR2C2 | NR2C2AP | NR2E1 | NR2E3 | NR2F1 | NR2F1-AS1 | NR2F2 | NR2F2-AS1 | NR2F6 | NR3C1 | NR3C2 | NR4A1 | NR4A2 | NR4A3 | NR5A1 | NR5A2 | NR6A1 | NRAD1 | NRADDP | NRAP | NRARP | NRAS | NRAV | NRBF2 | NRBF2P4 | NRBP1 | NRBP2 | NRCAM | NRDC | NRDE2 | NREP | NRF1 | NRG1 | NRG2 | NRG3 | NRG4 | NRGN | NRIP1 | NRIP2 | NRIP3 | NRIP3-DT | NRIR | NRK | NRL | NRM | NRN1 | NRN1L | NRON | NRP1 | NRP2 | NRROS | NRSN1 | NRSN2 | NRSN2-AS1 | NRTN | NRXN1 | NRXN2 | NRXN2-AS1 | NRXN3 | NSA2 | NSA2P2 | NSD1