GPR18: A Potential Drug Target and Biomarker for Various Diseases
GPR18: A Potential Drug Target and Biomarker for Various Diseases
G-protein coupled receptor 18 (GPR18) is a protein that plays an important role in cellular signaling. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a key role in cellular signaling. GPR18 is widely expressed in various tissues and is involved in a wide range of physiological processes, including sensory perception, neurotransmission, and hormone signaling.
GPR18 is a seven-transmembrane protein that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is involved in the formation of the receptor complex, which consists of the extracellular portion of the protein, the transmembrane domain, and the intracellular domain. The transmembrane domain is responsible for the transmembrane transportation of the receptor and is involved in the interaction with ligands. The intracellular domain is responsible for the internal signaling of the receptor and is involved in the interaction with intracellular signaling pathways.
GPR18 is involved in a wide range of physiological processes, including sensory perception, neurotransmission, and hormone signaling. For example, GPR18 is involved in the perception of touch and pressure and is thought to play a key role in the development of neuropathic pain. GPR18 is also involved in the transmission of neurotransmitters, such as dopamine and GABA, and is thought to play a key role in the regulation of neurotransmission.
GPR18 is a potential drug target in the treatment of various diseases. For example, GPR18 is known to be involved in the development of neuropathic pain and is thought to be a promising target for pain management. Additionally, GPR18 is involved in the regulation of neurotransmission and is thought to be involved in the development of various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
GPR18 is also a potential biomarker for various diseases. For example, GPR18 is known to be involved in the regulation of pain perception and is thought to be a potential biomarker for neuropathic pain. Additionally, GPR18 is involved in the regulation of neurotransmission and is thought to be a potential biomarker for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
In conclusion, GPR18 is a protein that plays an important role in cellular signaling and is involved in a wide range of physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPR18 is a potential drug target and biomarker for various diseases and is a promising target for the development of new therapies. Further research is needed to fully understand the role of GPR18 in cellular signaling and to develop effective treatments for the various diseases in which it is involved.
Protein Name: G Protein-coupled Receptor 18
Functions: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937)
The "GPR18 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPR18 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein | GPS1 | GPS2 | GPS2P1 | GPSM1 | GPSM2 | GPSM3 | GPT | GPT2 | GPX1 | GPX1P1 | GPX2 | GPX3 | GPX4 | GPX5 | GPX6 | GPX7 | GPX8 | GRAMD1A | GRAMD1B | GRAMD1C | GRAMD2A | GRAMD2B | GRAMD4 | GRAMD4P2 | GRAMD4P5 | GRAMD4P7 | Granzyme | GRAP | GRAP2 | GRAPL | GRAPL-AS1 | GRASLND | GRB10 | GRB14 | GRB2 | GRB7 | GREB1 | GREB1L | GREM1 | GREM1-AS1 | GREM2
