GPCR61: A G Protein-Coupled Receptor and Potential Drug Target

Target Name: GPR61

NCBI ID: G83873

GPR61

GPCR61: A G Protein-Coupled Receptor and Potential Drug Target

G Protein-Coupled Receptor 61 (GPCR61) is a G protein-coupled receptor that is expressed in various tissues and plays an important role in cellular signaling. It is one of the most abundant members of the GPCR family, and its function and potential as a drug target or biomarker have been the focus of extensive research in recent years.

GPCR61 is a transmembrane protein that is characterized by its extracellular domain, which consists of a N-terminal伪 helix, a 尾-sheet, and an C-terminal transmembrane region. The N-terminal伪 helix is 鈥嬧?媋 key structural element that plays a critical role in the formation of the GPCR61 dimer, while the 尾-sheet and C-terminal regions are involved in the protein's stability and interactions with ligands.

GPCR61 is involved in a wide range of physiological processes, including sensory perception, neurotransmission, and hormone signaling. It is a key receptor for several neurotransmitters, including nitric oxide, serotonin, and endothelin. GPCR61 has also been shown to play a role in the regulation of pain perception and inflammation.

GPCR61 has also been identified as a potential drug target and biomarker. Several studies have shown that GPCR61 is a potent inhibitor of neurotransmitter release, and that this activity can be modulated by small molecules such as pharmacological agents. For example, inhibition of GPCR61 has been shown to be effective in treating anxiety disorders, depression, and neurodegenerative diseases.

In addition to its potential as a drug target, GPCR61 has also been shown to be a useful biomarker for several diseases, including cancer, neurodegenerative diseases, and chronic pain. GPCR61 expression has been shown to be elevated in several types of cancer, including breast , ovarian, and prostate cancer. It has also been used as a biomarker for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

GPCR61 is also involved in several signaling pathways that are involved in disease progression and neurodegeneration. For example, GPCR61 has been shown to be involved in the regulation of mitochondrial function and energy metabolism, and its dysfunction has been implicated in the development of several neurological disorders , including Alzheimer's disease and Parkinson's disease.

In conclusion, GPCR61 is a G protein-coupled receptor that is involved in a wide range of physiological processes and has been identified as a potential drug target and biomarker. Its function and potential as a drug target or biomarker make it an attractive target for further research and development.

Protein Name: G Protein-coupled Receptor 61

Functions: Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity)

The "GPR61 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPR61 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets