GPR68: A Potential Drug Target for Neurotransmission, Inflammation and Metabolism

Target Name: GPR68

NCBI ID: G8111

GPR68

GPR68: A Potential Drug Target for Neurotransmission, Inflammation and Metabolism

GPR68 (MGC156983) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a critical role in cellular signaling. GPR68 has been identified as a potential drug target due to its involvement in a variety of physiological processes, including neurotransmission, inflammation, and metabolism.

The GPCR family is composed of different subfamilies, each of which is characterized by a specific mode of transduction. The most well-studied subfamily is the GPRCPR subfamily, which includes over 300 different proteins that are involved in a wide range of physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPR68 is a member of the GPRCPR subfamily and is characterized by its ability to interact with G protein-coupled receptors.

GPR68 is a 21-kDa protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the GPCR family and is characterized by its ability to interact with G protein-coupled receptors. GPR68 has been shown to play a critical role in a variety of physiological processes, including neurotransmission, inflammation, and metabolism.

One of the key functions of GPR68 is its role in neurotransmission. GPR68 is involved in the regulation of neurotransmitter release from axons in the central nervous system (CNS), including the neurotransmitter acetylcholine. Studies have shown that GPR68 plays a critical role in the regulation of neurotransmission by interacting with the neurotransmitter receptor, GABA-伪2. This interaction between GPR68 and GABA-伪2 allows GPR68 to modulate the release of neurotransmitters and influence brain function.

In addition to its role in neurotransmission, GPR68 is also involved in the regulation of inflammation. GPR68 has been shown to play a critical role in the regulation of inflammation by interacting with the transcription factor, NF-kappa-B. NF-kappa-B is a protein that is involved in the regulation of a wide range of cellular processes, including inflammation, cell growth, and survival. GPR68 has been shown to modulate the activity of NF-kappa-B and to play a role in the regulation of inflammation.

GPR68 is also involved in the regulation of metabolism. GPR68 has been shown to interact with the transcription factor, PPAR未. PPAR未 is a protein that is involved in the regulation of energy metabolism, including the production of fatty acids and the inhibition of lipid oxidation. GPR68 has been shown to modulate the activity of PPAR未 and to play a role in the regulation of metabolism.

Despite its involvement in a wide range of physiological processes, GPR68 is not yet a well-studied drug target. There is ongoing research into the potential mechanisms of GPR68 and its potential drug targets, including the modulation of neurotransmission, inflammation, and metabolism. Future studies are likely to provide further insights into the role of GPR68 in the regulation of physiological processes and the potential of GPR68 as a drug target.

In conclusion, GPR68 is a protein that is expressed in various tissues of the body and is involved in a variety of physiological processes, including neurotransmission, inflammation, and metabolism. Its involvement in these processes makes GPR68 a potential drug target, and further studies are likely to provide further insights into its role in the regulation of physiological processes and its potential as a drug.

Protein Name: G Protein-coupled Receptor 68

Functions: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity)

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•   protein biological mechanisms;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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