TRBV10-3: A Potential Drug Target for Cell Proliferation and Differentiation

Target Name: TRBV10-3

NCBI ID: G28583

TRBV10-3

Other Name(s): TCRBV10S3 | TRBV103 | T cell receptor beta variable 10-3 | TCRBV12S1A1N2

TRBV10-3: A Potential Drug Target for Cell Proliferation and Differentiation

TRBV10-3 (TcRBV10S3) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the T-cell receptor B (TCRB) family, which is a subclass of the T-cell receptor alpha chain. TRBV10-3 is known for its role in the regulation of cell proliferation and differentiation, and it is potential drug target for various diseases.

The TRBV10-3 protein is composed of 184 amino acid residues and has a calculated molecular weight of 21.9 kDa. It is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract, and it is primarily located in the cytoplasm. TRBV10-3 is a glycoprotein, which means that it consists of a protein that is covalently bound to a glycine molecule.

TRBV10-3 is involved in the regulation of cell proliferation and differentiation. It is a negative regulator of the T-cell receptor alpha chain, which is responsible for regulating the proliferation and differentiation of T cells. In addition, TRBV10-3 is involved in the regulation of cell adhesion and migration. It is a positive regulator of the cadherin protein, which is a transmembrane protein that is involved in cell-cell adhesion.

TRBV10-3 is also involved in the regulation of apoptosis, which is a process that is responsible for the programmed cell death that occurs in the body. It is a negative regulator of the p53 protein, which is a tumor suppressor protein that is involved in the regulation of apoptosis.

TRBV10-3 is a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. One of the main reasons for its potential as a drug target is its involvement in the regulation of cell proliferation and differentiation, which are processes that are critical for the development and progression of many diseases. In addition, TRBV10-3 is involved in the regulation of cell adhesion and migration, which are processes that are important for the recruitment and movement of immune cells to sites of infection or injury.

TRBV10-3 is also involved in the regulation of apoptosis, which is a process that is important for the regulation of cell death. Many diseases, including cancer, are characterized by the dysregulation of apoptosis, which allows cells to continue to divide and survive for too long. By targeting TRBV10-3, drugs can potentially inhibit the regulation of apoptosis and promote the programmed cell death that is necessary for the regulation of many diseases.

In conclusion, TRBV10-3 is a protein that is involved in the regulation of cell proliferation and differentiation, cell adhesion and migration, and apoptosis. Its potential as a drug target is due to its involvement in these processes, which are critical for the development and progression of many diseases. Further research is needed to fully understand the role of TRBV10-3 in the regulation of cell biology and to develop effective treatments for diseases that are characterized by the dysregulation of apoptosis.

Protein Name: T Cell Receptor Beta Variable 10-3

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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