TRBD1: A Potential Drug Target and Biomarker for T Cell Receptor Beta Diversity 1

Target Name: TRBD1

NCBI ID: G28637

TRBD1

Other Name(s): T cell receptor beta diversity 1 | TCRBD1

TRBD1: A Potential Drug Target and Biomarker for T Cell Receptor Beta Diversity 1

T cells are a crucial immune system cell that play a vital role in protecting the body against infections, viruses, and diseases. T cell receptor (TCR)尾 diversity 1 (TRBD1) is a gene that encodes the alpha chain of the TCR尾 receptor, which is responsible for recognizing antigens and triggering the immune response.TRBD1 gene has been identified as a potential drug target and biomarker for TCR尾 diversity 1 due to its unique structure and function.

TRBD1 gene encodes a 194 amino acid protein that is highly conserved across different species, including humans. The protein has a unique structure that consists of a variable region, a constant region, and a variable region. The variable region is the most variable part of the protein and is responsible for the recognition of antigens. The constant region is responsible for the stability of the protein, and the variable region is responsible for the recognition of antigens.

TRBD1 is a key gene that is involved in the development and regulation of T cell receptor (TCR)尾 diversity 1. TCR尾 diversity 1 is a gene that encodes the alpha chain of the TCR尾 receptor, which is responsible for recognizing antigens and triggering the immune response. The TRBD1 gene is responsible for the production of the alpha chain of the TCR尾 receptor, which is a critical component of the T cell immune response.

TRBD1 is a unique gene that has not been studied extensively. Despite its importance in the immune system, TRBD1 has not been identified as a potential drug target or biomarker. However, recent studies have suggested that TRBD1 may be a potential drug target and biomarker for TCR尾 diversity 1.

One of the studies that suggested the potential of TRBD1 as a drug target is the finding that TRBD1 is highly expressed in human tissues and that it is involved in the regulation of immune responses. The authors of the study found that TRBD1 was highly expressed in tissues such as lymph nodes, spleen, and Peyer's patches, which are important sites of T cell activation and proliferation. The authors also found that TRBD1 was involved in the regulation of immune responses, including T cell activation and proliferation.

Another study that suggested the potential of TRBD1 as a biomarker for TCR尾 diversity 1 is the finding that TRBD1 is associated with the development of certain diseases. The authors of the study found that individuals with certain genetic variations in the TRBD1 gene are at increased risk of developing diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. The authors also found that these individuals had lower levels of TCR尾 diversity 1 in their blood.

In conclusion, TRBD1 is a gene that encodes the alpha chain of the TCR尾 receptor, which is responsible for recognizing antigens and triggering the immune response. The TRBD1 gene has not been studied extensively, but recent studies have suggested that it may be a potential drug target and biomarker for TCR尾 diversity 1. Further research is needed to confirm these findings and to explore the potential of TRBD1 as a drug target and biomarker.

Protein Name: T Cell Receptor Beta Diversity 1

Functions: D region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRBD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRBD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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