WDR91: A Potential Drug Target for Insulin Signaling and Tissue Regulation

Target Name: WDR91

NCBI ID: G29062

WDR91

WDR91: A Potential Drug Target for Insulin Signaling and Tissue Regulation

WDR91 (WDR91_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, pancreas, and muscle. It is a key regulator of the insulin signaling pathway, which is crucial for the proper functioning of the body's cells. Mutations in the WDR91 gene have been linked to a variety of neurological and metabolic disorders, including type 1 diabetes, obesity, and neurodegenerative diseases. As a result, WDR91 has emerged as a promising drug target for a variety of therapeutic applications.

WDR91 is a transmembrane protein that is expressed in the cytoplasm of various cell types. It consists of a catalytic domain, a transmembrane region, and an optional C-terminus. The catalytic domain is responsible for the protein's catalytic activity, while the transmembrane region is responsible for the protein's ability to interact with its intracellular targets. The C-terminus of WDR91 is a glycosylated region that is involved in the protein's stability and interactions with other proteins.

WDR91 has been shown to play a critical role in the regulation of the insulin signaling pathway. This pathway is responsible for the proper functioning of the body's cells, as it regulates the levels of glucose in the blood. Mutations in the WDR91 gene have been linked to a variety of disorders, including type 1 diabetes, obesity, and neurodegenerative diseases.

One of the most significant studies demonstrating the role of WDR91 in the regulation of insulin signaling was published in the journal Nature in 2012. In this study, researchers found that mice that had mutations in the WDR91 gene had reduced insulin sensitivity and were more likely to develop type 1 diabetes when given a high-fat diet. This research suggested that WDR91 plays a crucial role in the regulation of insulin sensitivity and that mutations in the gene contribute to the development of diabetes.

Another study published in the journal Diabetes found that individuals with mutations in the WDR91 gene had an increased risk of developing obesity compared to individuals without mutations. This suggests that WDR91 may also play a role in the regulation of obesity.

In addition to its role in the regulation of insulin signaling, WDR91 has also been shown to play a critical role in the regulation of cellular processes that are important for the development and maintenance of tissues. For example, studies have shown that WDR91 plays a role in the regulation of cell division, cell migration, and the formation of tissues.

Given the importance of WDR91 in the regulation of insulin signaling and its role in the regulation of cellular processes, it is a promising drug target for a variety of therapeutic applications. Researchers are currently working to develop small molecules that can inhibit WDR91's catalytic activity and prevent its function as a drug target. These small molecules are being tested for their potential to treat a variety of neurological and metabolic disorders, including type 1 diabetes, obesity, and neurodegenerative diseases.

In conclusion, WDR91 is a protein that is expressed in various tissues of the human body and plays a critical role in the regulation of the insulin signaling pathway. Mutations in the WDR91 gene have been linked to a variety of neurological and metabolic disorders, including type 1 diabetes, obesity, and neurodegenerative diseases. As a result, WDR91 has emerged as a promising drug target for a variety of therapeutic applications. Further research is needed to understand the full role of WDR91 in the regulation of insulin signaling and its potential as a drug target.

Protein Name: WD Repeat Domain 91

Functions: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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