GTF2H4: A Potential Drug Target and Biomarker for Fibrosis and Chronic Pain

Target Name: GTF2H4

NCBI ID: G2968

GTF2H4

GTF2H4: A Potential Drug Target and Biomarker for Fibrosis and Chronic Pain

Fibrosis and chronic pain are significant public health issues that affect millions of people worldwide. Fibrosis is a pathological process that involves the excessive growth and reorganization of cells, leading to the formation of tissue-specific structures, such as tumors, scar tissue, and fibrotic tissue. Chronic pain, on the other hand, is a persistent and debilitating sensation that can have a significant impact on an individual's quality of life.

The GTF2H4 (Transcriptional factor IIH subunit) is a protein that plays a crucial role in the regulation of gene expression and cell proliferation. It is a part of the TFIIH (Transcriptional factor IIH) complex, which is a protein-coding complex that plays a central role in the regulation of gene expression. GTF2H4 is composed of two subunits, GTF2H4A and GTF2H4B, that are capable of binding to specific DNA sequences and regulating the activity of chromatin-remodeling enzymes.

Recent studies have identified GTF2H4 as a potential drug target and biomarker for fibrosis and chronic pain. The high level of interest in GTF2H4 is due to its involvement in the regulation of key cellular processes that are associated with the development and progression of fibrosis and chronic pain.

Disease-Related Processes

Fibrosis is a complex pathological process that involves the activation of multiple signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell proliferation, differentiation, and inflammation, and is a key factor in the development of fibrosis.

Chronic pain is associated with the activation of nociceptive neurons, which release inflammatory mediators that can further exacerbate pain. The nociceptive neurons are also involved in the regulation of pain perception and the development of pain tolerance.

GTF2H4 Role in Fibrosis

Several studies have demonstrated that GTF2H4 is involved in the regulation of key processes that are associated with the development and progression of fibrosis.

First, GTF2H4 is involved in the regulation of the TGF-β pathway. TGF-β is a key transcription factor that is involved in the regulation of cell proliferation, differentiation, and inflammation. GTF2H4 has been shown to play a role in the regulation of TGF-β activity, by binding to its DNA and preventing its transcriptional activity.

Second, GTF2H4 is involved in the regulation of the cell cycle. The cell cycle is the process by which cells grow, divide, and replicate their genetic material. GTF2H4 has been shown to play a role in regulating the length of the G1 phase of the cell cycle, which is the phase of cell growth and preparation for cell division.

Third, GTF2H4 is involved in the regulation of the inflammatory response. Fibrotic tissue is a site of chronic inflammation, and GTF2H4 has been shown to play a role in the regulation of the inflammatory response, by preventing the production of pro-inflammatory cytokines.

Fourth, GTF2H4 is involved in the regulation of the cell adhesion process. Fibrotic tissue is composed of cells that have lost their cell-cell adhesion, and GTF2H4 has been shown to play a role in the regulation of cell-cell adhesion, by preventing the loss of tight junctions.

Disease-Related Applications

The potential applications of GTF2H4 as a drug target and biomarker for fibrosis and chronic pain are significant. If GTF2H4 is successfully targeted, it may lead to the development of new therapeutic approaches for the treatment of fibrosis and chronic pain.

One potential approach to targeting GTF2H4 is the use of small molecules that can inhibit its activity.

Protein Name: General Transcription Factor IIH Subunit 4

Functions: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription

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